摘要
目的研究膝关节镜下微骨折术对膝关节软骨损伤患者膝关节功能与关节液炎性因子水平的影响。方法选取2019年6月至2020年6月吉林市人民医院收治的150例膝关节软骨损伤患者,按照随机数字表法分组。对照组(75例)患者实施关节镜下关节清理术,观察组(75例)患者实施关节镜下微骨折术。比较两组患者术后6个月临床疗效,术前与术后2周关节液肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、基质金属蛋白酶-13(MMP-13)水平,术前与术后6个月美国纽约特种外科医院(HSS)评分、Tegner活动水平评定量表评分,术后并发症发生情况。结果观察组患者临床总有效率显著高于对照组;与术前比,两组患者术后2周关节液炎性因子水平均显著下降,术后6个月膝关节功能评分均显著升高,观察组改善情况显著优于对照组(均P<0.05);两组患者并发症总发生率比较,差异无统计学意义(P>0.05)。结论膝关节镜下微骨折术治疗膝关节软骨损伤患者,可提高其治疗效果,改善膝关节功能,降低关节腔内炎症反应,促进软骨修复,安全性良好。
Objective To study the effects of knee arthroscopic microfractures on knee joint function and synovial fluid inflammatory factors in patients with knee cartilage injury.Methods 150 cases of knee cartilage injury patients admitted to Jilin People’s Hospital from June 2019 to June 2020 were selected and grouped according to the random number table method.The control group(75 cases)underwent arthroscopic joint debridement,and the observation group(75 cases)underwent knee arthroscopic microfracture.The clinical efficacy of the two groups at 6 months after surgery,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),matrix metalloproteinase-13(MMP-13)in the synovial fluid before and 2 weeks after surgery,New York Hospital for Special Surgery(HSS)score,Tegner activity scale before and 6 months after surgery and postoperative complications were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group;Compared with before surgery,the inflammatory factors in the synovial fluid of the two groups decreased at 2 weeks after surgery,and the knee joint function scores increased at 6 months after surgery,the improvement of the observation group was better than that of the control group(all P<0.05);There was no statistically difference in the total incidence of complications between the two groups(P>0.05).Conclusion Knee arthroscopic microfractures in patients with knee cartilage iinjury can improve the therapeutic effect,improve knee joint function,reduce inflammation in the articular fluid,promote cartilage repair,and with good security.
作者
刘柏铭
谷建彬
杨慧欣
王健
LIU Boming;GU Jianbin;YANG Huixin;WANG Jian(Department of Sports Medicine,Jilin People’s Hospital,Jilin,Jilin 132001,China)
