摘要
目的探讨异基因造血干细胞移植(allo-HSCT)患者血清中碱性磷酸酶(ALP)和γ-谷氨酰转移酶(GGT)水平变化及其与预后的关系。方法2017年1月至2019年12月我科收治的allo-HSCT患者97例,分析allo-HSCT患者急性移植物抗宿主病(aGVHD)发生情况,依据患者是否发生aGVHD分为aGVHD组和未aGVHD组,随访两组预后情况,并分析影响allo-HSCT患者发生aGVHD的危险因素。结果97例allo-HSCT患者共发生aGVHD 48例,发生率为49.48%(48/97),其中28例为Ⅰ~Ⅱ度(28.87%)、20例为Ⅲ~Ⅳ度(20.62%)。与allo-HSCT前比较,allo-HSCT后患者血清ALP、GGT水平明显增高,差异有统计学意义(P<0.05)。aGVHD组年龄≥40岁、HLA配型为不全相合、血清ALP、GGT水平较无aGVHD组明显高(P<0.05),年龄、HLA配型、血清ALP、GGT水平是allo-HSCT患者aGVHD发生的危险因素(P<0.05)。结论allo-HSCT患者移植后aGVHD发生风险高,allo-HSCT患者血清中ALP、GGT水平表达呈增高趋势,临床需重视对高龄、HLA配型不全相合的allo-HSCT患者血清ALP、GGT水平的监测,对allo-HSCT患者预后的改善有积极意义。
Objective To explore the changes in levels of serum alkaline phosphatase(ALP)andγ-glutamyltransferase(GGT)in patients undergoing allogeneic hematopoietic stem cell transplantation(allo-HSCT)and their relationships with prognosis.Methods A total of 97 allo-HSCT patients who were admitted to our department from January,2017 to December,2019 were enrolled for the study.The occurrence of acute graft-versus-host disease(aGVHD)in allo-HSCT patients was analyzed.According to presence or absence of aGVHD,all patients were divided into the aGVHD group and non-aGVHD group.The prognosis in both groups was followed up.The risk factors of aGVHD were analyzed.Results Of the 97 allo-HSCT patients,there were 48 cases[49.48%(48/97)]with aGVHD,including 28 cases at grade I-II(28.87%)and 20 cases at grade III-IV(20.62%).After allo-HSCT,levels of serum ALP and GGT were significantly increased(P<0.05).The proportions of patients with age not younger than 40 years old and incomplete consistency of HLA matching,levels of serum ALP and GGT in the aGVHD group were all significantly higher than those in the non-aGVHD group(P<0.05).Age,HLA matching,serum ALP and GGT levels were risk factors of aGVHD in allo-HSCT patients(P<0.05).Conclusion After allo-HSCT,aGVHD risk is high in patients.The levels of serum ALP and GGT are increased in allo-HSCT patients.Clinically,the monitoring results of serum ALP and GGT levels in allo-HSCT patients with elderly age and incomplete HLA matching should be paid more attentions to,which is of positive significance in improving prognosis of allo-HSCT patients.
作者
袁韵
胡艳
卢丹
YUAN Yun;HU Yan;LU Dan(Department of Hematology, West China Hospital, Sichuan University,West China School of Nursing,Sichuan University, Chengdu 610041, China)
出处
《标记免疫分析与临床》
CAS
2021年第4期591-595,共5页
Labeled Immunoassays and Clinical Medicine
基金
四川省卫生厅科研项目(编号:150115)。
关键词
异基因造血干细胞移植
ALP
GGT
预后
Allogeneic hematopoietic stem cell transplantation
ALP
GGT
Prognosis
