摘要
目的观察不同负荷剂量右美托咪定(Dex)预防经尿道前列腺电切(TURP)术后导尿管相关膀胱刺激征(CRBD)的效果。方法选取择期行前列腺电切术患者120例,随机分为A,B,C 3组,每组40例。全麻诱导前给予A,B组患者右美托咪定0.5μg/kg,1μg/kg,10min内泵注完成,随后以0.2μg/(kg·h)的浓度维持,直至手术结束前30min停药;C组患者给与等体积0.9%生理盐水。记录术后30min(T1)、2h(T2)、6h(T3)CRBD严重程度评分、Riker镇静-躁动评分、VAS评分以及不良事件发生情况。结果A,B组术后CRBD发生率显著低于C组(P<0.05),且B组在T1,T2时刻CRBD发生率显著低于A组(P<0.05);与C组相比,A,B组在T1,T2,T3时刻VAS评分显著降低(P<0.05),两组间差异无统计学意义(P>0.05);与C组相比,A,B组在T1,T2时刻Riker镇静-躁动评分明显降低(P<0.05),且B组显著低于A组(P<0.05)。结论全麻诱导前10min给予1μg/kg Dex更有助于减轻行TURP患者术后CRBD发生率,并具有更好的镇静效果。
Objective To observe the effects of dose-dependence of dexmedetomidine(Dex)on catheter-related bladder discomfort(CRBD)in patients undergoing transurethral resection of prostate(TURP).Methods A total of 120 male patients,undergoing TURP,aged 60~80 years,with BMI 18~25 kg/m2,were randomly divided into 3 groups(group A,group B and group C),equal samples in each group.Patients in Group A and B were administrated 0.5μg/kg or 1μg/kg Dex respectively by intravenous pumping 10 mins before induction of anesthesia,and then Dex 0.2μg/(kg·h)had been continuously given in both groups till 30 mins before the surgery ended;Group C received equivalent normal saline instead of Dex.CRBD graded scores,VAS scores,Riker scores and adverse events were assessed at 30 min(T1),2 h(T2),6 h(T3)after surgery.Results The CRBD scores of both Group A and Group B were significantly lower than those of Group C(P<0.05),and the CRBD scores of Group B were significantly lower than those of Group A at the time point of T1 and T2(P<0.05).Compared with Group C,the VAS scores of Group A and Group B were significantly lower at T1,T2 and T3(P<0.05),but there was no difference between Group A and Group B(P>0.05).The Riker scores of Group A and Group B were significantly lower than Group C at T1 and T2(P<0.05),and the Riker scores of Group B were significantly lower than Group A at T1 and T2(P<0.05).Conclusion Preoperative administration of Dex at 1μg/kg has more efficiency in reducing the incidence of CRBD,and ameliorates the sedative effect as well.
作者
李沅君
周静竹
朱腾
韩慧蓉
王桂芝
LI Yuanjun;ZHOU Jingzhu;ZHU Teng;HAN Huirong;WANG Guizhi(School of Anesthesiology,Weifang Medical University,Weifang 261053,China)
出处
《潍坊医学院学报》
2021年第2期87-89,共3页
Acta Academiae Medicinae Weifang
