摘要
目的对卡马西平联合丙戊酸钠治疗额叶癫痫的效果进行探讨。方法选取2018年2月—2020年5月期间收治的86例额叶癫痫患者进行研究,采用信封抽签的方式分成两组实施研究,分别为对照组及观察组,每组43例,对照组单纯给予卡马西平治疗,观察组联合丙戊酸钠治疗,对比两组患者治疗效果、脑功能评分情况、发作次数、持续时间及服药后出现的不良反应。结果观察组治疗有效率95.35%与对照组72.09%比较,差异有统计学意义(χ^(2)=8.532,P<0.05);观察组治疗后MOCA评分(25.35±4.04)分,显著高于对照组(21.14±3.89)分,差异有统计学意义(t=4.922,P<0.05);观察组每日发作次数(1.15±1.08)次,少于对照组(2.34±1.62)次;每次持续时间(1.25±1.06)min,短于对照组(2.15±1.12)min,差异有统计学意义(t=4.008、3.827,P<0.05);观察组出现不良反应4例(9.30%),与对照组不良反应5例(11.63%)对比差异无统计学意义(χ^(2)=0.000,P>0.05)。结论针对额叶癫痫患者,卡马西平联合丙戊酸钠治疗可改善患者的脑功能,缩短其发作次数及持续时间,与单一药物比较,并未显著增加不良反应的发生。
Objective To explore the effect of carbamazepine combined with sodium valproate in the treatment of frontal lobe epilepsy.Methods Eighty-six patients with frontal lobe epilepsy admitted from February 2018 to May 2020 were selected for the study.The envelop drawing method was used to divide them into two groups for the study,namely the control group and the observation group,with 43 cases in each group,and the control group Carbamazepine was given only treatment,the observation group was combined with sodium valproate treatment,and the treatment effect,brain function score,number of attacks,duration and adverse reactions after taking the drug were compared between the two groups.Results Compared with the treatment effective rate of 95.35%in the observation group and 72.09%in the control group,the difference was statistically significant(χ^(2)=8.532,P<0.05);the MOCA score of the observation group after treatment was(25.35±4.04)points,which was significantly higher than that of the control group(21.14±3.89)points,the difference was statistically significant(t=4.922,P<0.05);the number of attacks per day in the observation group was(1.15±1.08)times,which was less than the control group(2.34±1.62)times;the duration of each time was(1.25±1.06)min,which was shorter than the control group(2.15±1.12)min,the difference was statistically significant(t=4.008,3.827,P<0.05);4 cases of adverse reactions(9.30%)occurred in the observation group,and there was no statistically significant difference compared with 5 cases(11.63%)of the control group,the difference was not statistically significant(χ^(2)=0.000,P>0.05).Conclusion For patients with frontal lobe epilepsy,carbamazepine combined with sodium valproate therapy can improve the brain function of patients,and shorten the number and duration of seizures.Compared with a single drug,it does not significantly increase the occurrence of adverse reactions.
作者
赵维元
ZHAO Weiyuan(The Fifth Department of Internal Medicine,Ningjin County People's Hospital,Dezhou,Shandong Province,253400 China)
出处
《世界复合医学》
2021年第4期149-151,共3页
World Journal of Complex Medicine
关键词
卡马西平
丙戊酸钠
额叶癫痫
效果
Carbamazepine
Sodium valproate
Frontal lobe epilepsy
Effect
