摘要
目的观察葛根和绞股蓝提取物与红曲配伍制成的胶囊制剂对实验性高血脂大鼠的降血脂作用。方法将40只SPF级雄性大鼠随机分为模型对照组和受试物低(200 mg/kg·bw)、中(400 mg/kg·bw)、高(800 mg/kg·bw)剂量组,每组10只。模型对照组喂饲高脂饲料以诱导高脂血症模型,各剂量组给予高脂饲料喂养并灌胃不同浓度葛根和绞股蓝提取物与红曲配伍制剂。连续灌胃30 d后,测定各组大鼠血清总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)水平。根据《保健食品检验与评价技术规范》降血脂检测评价方法判断受试制剂的降血脂作用。结果干预前、中、后期,各组间大鼠体质量变化差异无统计学意义(P>0.05)。造模后,模型对照组大鼠血清TC、TG均明显升高(P<0.01),HDL-C明显降低(P<0.01)。中剂量组大鼠血清TG为(1.17±0.23)mmol/L,明显低于模型对照组(P<0.05);高剂量组大鼠血清TC为(2.99±0.49)mmol/L、TG为(1.10±0.45)mmol/L,均明显低于模型对照组(P<0.05),且血清HDL-C水平高于模型对照组(P<0.05)。结论高剂量组葛根和绞股蓝提取物与红曲配伍制剂对实验性高脂血症大鼠具有较好的辅助降血脂作用。
Objective To observe the hypolipidemic effect of extracts from radix puerariae and gynostemma pentaphyllum combined with red yeast rice in hyperlipidemia mice.Methods Fourty SPF male mice were randomly divided into model control group and low-dose(200 mg/kg·bw),medium-dose(400 mg/kg·bw),high-dose(800 mg/kg·bw)group,with ten rats in each group.The model control group was given high-fat diet to induce hyperlipidemia model.Each dose group was given high-fat diet and different concentrations of extracts from radix puerariae and gynostemma pentaphyllum combined with red yeast rice preparation.The serum levels of total cholesterol(TC),triacylglycerol(TG)and high-density lipoprotein cholesterol(HDL-C)were measured after continuously oral administration for 30 days.The effect of hypolipidemic of the preparation was judged according to the assessment of reducing blood lipids in Technical Standards for Testing and Assessment of Health Food.Results There was no significant difference in body mass of rats before and after intervention(P>0.05).The serum levels of TC and TG in the model control group were significantly increased(P<0.01),while the level of HDL-C was significantly decreased(P<0.01).The level of TG in medium-dose group was significantly lower than that in model control group(P<0.05).The levels of TC and TG in high-dose group were significantly lower than that in model control group(P<0.05).The level of HDL-C in high-dose group was significantly higher than that in model control group(P<0.05).Conclusion The extracts from radix puerariae and gynostemma pentaphyllum combined with red yeast rice of high-dose group in this study has the function of reducing blood lipids.
作者
孙川喻
郝超宝
王宏伟
SUN Chuanyu;HAO Chaobao;WANG Hongwei(Department of Clinical Nutrition,People’s Hospital of Rizhao,Rizhao 276800,China;Department of Neurosurgery,People’s Hospital of Rizhao,Rizhao 276800,China)
出处
《中西医结合研究》
2021年第3期174-177,共4页
Research of Integrated Traditional Chinese and Western Medicine
关键词
葛根
股绞蓝
红曲
血脂
高脂血症
radix puerariae
gynostemma pentaphyllum
red yeast rice
blood lipids
hyperlipidemia
