摘要
目的探究重组人生长激素(RH-GH)对行体外受精-胚胎移植(IVF-ET)助孕的卵巢功能减退(DOR)不孕患者的影响。方法选取200例行IVF-ET助孕的DOR不孕患者,采用随机数字表法分为研究组与对照组,各100例。研究组患者应用RH-GH,对照组患者未应用RH-GH,观察并比较两组促性腺激素(Gn)用量、Gn使用时间、人绒毛膜促性腺激素(HCG)日雌二醇(E_(2))值、获卵数、可利用胚胎数及优质胚胎数。结果研究组Gn用量(1849.27±514.23)IU少于对照组的(2260.01±584.56)IU,Gn使用时间(8.01±2.13)d明显短于对照组的(8.84±2.54)d,HCG日E_(2)值(1774.62±361.23)pg/ml明显高于对照组的(1512.37±274.86)pg/ml,获卵数(6.55±2.14)枚明显多于对照组的(5.98±1.54)枚,可利用胚胎数(4.58±0.95)枚明显多于对照组的(4.28±0.92)枚,优质胚胎数(3.54±0.81)枚明显多于对照组的(2.33±0.51)枚,差异有统计学意义(P<0.05)。结论RH-GH对行IVF-ET的DOR不孕患者助孕效果显著,能有效减少Gn的用量与使用时间,增加HCG日激素水平、获卵数及可利用胚胎数、优质胚胎数。
Objective To investigate the effect of recombinant human growth hormone(RH-GH)on infertile patients with hypoovarian function(DOR)assisted by in vitro fertilization and embryo transfer(IVF-ET).Methods Two hundred infertile DOR patients with IVF-ET assisted pregnancy were divided into study group and control group by random number table method,100 cases in each group.The study group received RH-GH,while the control group did not receive RH-GH.The dosage of gonadotropin(Gn),the use time of Gn,the daily estradiol(E_(2))value of human choronic gonadotropin(HCG),the number of eggs obtained,the number of usable embryos and the number of high-quality embryos were observed and compared between the two groups.Results The dosage of Gn in the study group(1849.27±514.23)IU was less than that in the control group(2260.01±584.56)IU,and the duration of Gn in the study group(8.01±2.13)d was significantly shorter than that in the control group(8.84±2.54)d.The E_(2) value of HCG day(1774.62±361.23)pg/ml was significantly higher than that of control group(1512.37±274.86)pg/ml,and the number of eggs(6.55±2.14)was significantly higher than that of control group(5.98±1.54).The number of available embryos(4.58±0.95)was significantly higher than that of the control group(4.28±0.92),the number of high-quality embryos(3.54±0.81)was significantly higher than that of the control group(2.33±0.51),the difference was statistically significant(P<0.05).Conclusion RH-GH can effectively reduce the dosage and duration of Gn,increase the daily hormone level of HCG,the number of eggs obtained,the number of available embryos and the number of high-quality embryos in infertile patients with DOR treated with IVF-ET.
作者
朱玲玲
王缉义
Zhu Lingling;Wang Jiyi(Department of Reproductive Medicine,Yulin Maternal and Child Health Hospital,Yulin,Guangxi 537000,China;Yulin maternal and child health care hospital,Pharmacy Department,Yulin,Guangxi 537000,China)
出处
《实用妇科内分泌电子杂志》
2021年第6期40-42,共3页
Electronic Journal of Practical Gynecological Endocrinology
关键词
卵巢功能减退
体外受精-胚胎移植
重组人生长激素
Ovarian dysfunction
In vitro fertilization-embryo transfer
Recombinant human growth hormone
