摘要
目的探讨芪参益气滴丸联合比索洛尔治疗左心室射血分数保留性心力衰竭(HFPEF)的疗效及对氧化应激和心室重构的影响。方法选取2017年7月—2019年8月我院收治的HFPEF病人98例,根据随机数字表法分为对照组与研究组,每组49例。对照组予以比索洛尔治疗,研究组在对照组基础上联合芪参益气滴丸治疗,比较两组临床疗效、氧化应激和心室重构变化情况,记录两组治疗期间不良反应发生情况。结果研究组治疗3个月后临床总有效率高于对照组(P<0.05)。两组治疗3个月后髓过氧化酶(MPO)较治疗前降低,超氧化物歧化酶(SOD)较治疗前升高(P<0.05);研究组治疗3个月后MPO低于对照组,SOD则高于对照组(P<0.05)。两组治疗3个月后左心室射血分数(LVEF)、6 min步行试验距离(6MWT)较治疗前升高,左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)较治疗前降低(P<0.05);研究组治疗3个月后LVESD、LVEDD低于对照组,LVEF、6MWT则高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论芪参益气滴丸联合比索洛尔治疗HFPEF,疗效较好,可有效减轻机体氧化应激反应,缓解心室重构,且用药安全性较好。
Objective To observe the efficacy of Qishen Yiqi Dropping Pill combined with bisoprolol in the treatment of left ventricular ejection fraction retained heart failure and its effect on oxidative stress and ventricular remodeling.Methods Ninety-eight left ventricular ejection fraction retained heart failure patients were were randomly divided into the control group and the treatment group,with 49 cases in each group.The patients in the control group were treated with bisoprolol and the patients in treatment group were treated with Qishen Yiqi Dropping Pill on the basis of the control group.The changes of clinical efficacy,oxidative stress,ventricular remodeling and adverse reactions were compared between two groups.Results After 3 months of treatment,the total clinical efficacy of the treatmeat group was better than that of the control group(P<0.05).After 3 months of treatment,myeloperoxidase(MPO)of two groups decreased,and MPO in the treatment group was lower than that in the control group(P<0.05).After 3 months of treatment,superoxide dismutase(SOD)of two groups increased,and SOD in the treatment group was higher than that in the control group(P<0.05).After 3 months of treatment,left ventricular ejection fraction(LVEF)and 6 minute walk test(6MWT)of two groups increased,and LVEF and 6MWT in the treatment group were higher than those in the control group(P<0.05).After 3 months of treatment,left ventricular end systolic diameter(LVESD)and left ventricular end diastolic diameter(LVEDD)decreased(P<0.05),LVESD and LVEDD in the treatment group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Qishen Yiqi Dropping Pill combined with bisoprolol in the treatment of left ventricular ejection fraction retained heart failure was effective,which could effectively alleviate oxidative stress,and ventricular remodeling,with better safety and clinical application value.
作者
张丹
勾韦华
ZHANG Dan;GOU Weihua(Qingyang People′s Hospital,Qingyang 745000,Gansu,China)
出处
《中西医结合心脑血管病杂志》
2021年第11期1844-1847,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
甘肃省卫生行业科研计划项目(No.GSWSKY2017-023)。
关键词
左心室射血分数保留性心力衰竭
芪参益气滴丸
比索洛尔
氧化应激
心室重构
left ventricular ejection fraction retained heart failure
Qishen Yiqi Dropping Pill
Bisoprolol
oxidative stress
ventricular remodeling
