摘要
目的:探讨糖脉康颗粒联合西洛他唑治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的临床疗效。方法:选取2018年4月至2019年12月佛山市中医院收治的DPN患者80例,根据随机分层抽样法分为对照组40例(西洛他唑治疗)和观察组40例(在对照组的基础上联合糖脉康颗粒治疗)。观察两组患者的临床疗效、血糖指标、血清指标、神经传导速度及不良反应发生情况。结果:治疗3个月后,两组患者糖化血红蛋白(HbA 1c)、空腹血糖及餐后2 h血糖(2 hPG)水平均较治疗前明显降低,且观察组患者HbA 1c、空腹血糖及2 hPG水平明显低于对照组,差异均有统计学意义(P<0.05)。观察组、对照组患者的临床总有效率分别为92.50%(37/40)、72.50%(29/40),观察组患者明显高于对照组,差异均有统计学意义(P<0.05)。治疗3个月后,两组患者丙二醛(MDA)、肿瘤坏死因子α(TNF-α)及白细胞介素6(IL-6)水平均较治疗前明显降低,超氧化物歧化酶(SOD)水平较治疗前明显升高;且观察组患者MDA、TNF-α及IL-6水平明显低于对照组,SOD水平明显高于对照组,差异均有统计学意义(P<0.05)。治疗3个月后,两组患者腓总神经运动神经传导速度(MCV)、感觉神经传导速度(SCV),正中神经MCV、SCV均较治疗前明显升高,且观察组患者明显高于对照组,差异均有统计学意义(P<0.05)。对照组、观察组患者的不良反应发生率分别为12.50%(5/40)、17.50%(7/40),差异无统计学意义(P>0.05)。结论:糖脉康颗粒联合西洛他唑治疗DPN,可有效控制患者血糖,改善神经传导速度,且安全可靠,其主要作用机制可能与调节SOD、MDA、TNF-α及IL-6等细胞因子水平有关。
OBJECTIVE:To probe into the clinical efficacy of Tangmaikang granules combined with cilostazol in the treatment of diabetic peripheral neuropathy(DPN).METHODS:Totally 80 patients with DPN admitted into Foshan Hospital of Traditional Chinese Medicine from Apr.2018 to Dec.2019 were extracted to be divided into the control group(treated with cilostazol)and the observation group(treated with Tangmaikang granules on the basis of the control group)via the random number table,with 40 cases in each group.The clinical efficacy,blood glucose index,serum index,nerve conduction velocity and the incidence of adverse drug reactions of two groups were observed.RESULTS:After treatment of 3 months,the levels of glycosylated hemoglobin(HbA 1c),fasting blood glucose and 2 h postprandial blood glucose(2 hPG)in both groups were significantly lower than those before treatment,and the levels of HbA1c,fasting blood glucose and 2 hPG in the observation group were significantly lower than those in the control group,with statistically significant difference(P<0.05).The total clinical effective rates of the observation group and the control group were respectively 92.50%(37/40)and 72.50%(29/40),and the observation group was significantly higher than the control group,with statistically significant difference(P<0.05).After treatment of 3 months,compared with before treatment,the levels of malondialdehyde(MDA),tumor necrosis factor(TNF-α)and interleukin 6(IL-6)in both groups decreased significantly,while the level of superoxide dismutase(SOD)increased significantly;the levels of MDA,TNF-α and IL-6 in the observation group were significantly lower than those in the control group,and the level of SOD was significantly higher than that in the control group,the differences were statistically significant(P<0.05).After treatment of 3 months,the motor nerve conduction velocity(MCV),sensory nerve conduction velocity(SCV),median nerve MCV and SCV in both groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group,the differences were statistically significant(P<0.05).The incidences of adverse drug reactions in the control group and observation group were respectively 12.50%(5/40)and 17.50%(7/40),the difference was not statistically significant(P>0.05).CONCLUSIONS:Tangmaikang granules combined with cilostazol in the treatment of DPN can effectively control the blood glucose in patients,improve the nerve conduction velocity with higher safety.The main mechanism of action may be related to the regulation of SOD,MDA,TNF-α and IL-6 and other cytokine levels.
作者
刘晓霞
刘天
何东盈
魏爱生
LIU Xiaoxia;LIU Tian;HE Dongying;WEI Aisheng(Dept.of Endocrinology,Foshan Hospital of Traditional Chinese Medicine,Guangdong Foshan 528000,China)
出处
《中国医院用药评价与分析》
2021年第5期560-562,566,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
广东省中医药局科研项目(No.20182147)。
