摘要
补体1q/肿瘤坏死因子相关蛋白9(CTRP9)是高度保守的脂联素旁系同源物,具有与脂联素相似的结构及功能。大量证据表明其是一种有效的心脏保护性脂肪因子,尽管也有少数研究发现CTRP9对心脏不利。本文将探讨CTRP9的结构与表达、信号途径及其在心血管疾病中的作用。
Complement 1q(C1q)/tumor necrosis factor-related protein 9(CTRP9)is a highly conservative adiponectin paralogue,which has similar structure and function to adiponectin.Although few studies found it is unfavorable for the heart,plenty of evidences support that CTRP9 is a cardio-protective adipokine.This paper will review the structure,expression profile and associated signaling pathways of CTRP9 and its role in cardiovascular disease.
作者
杨明媚
曾敏
Yang Mingmei;Zeng Min(Medical Care Center the Third Wad,Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, China)
出处
《中国心血管杂志》
2021年第3期306-309,共4页
Chinese Journal of Cardiovascular Medicine
基金
国家自然科学基金(81100153、81260043、81760054)
海南省自然科学基金(ZDXM2014065、2016CXTD011、2019RC367)。
