摘要
为构建精神障碍药品不良反应(ADR)风险因素评价指标体系,提出一种基于粗糙集理论的ADR风险评价指标方法。以某医院2012年1月-2019年6月精神障碍患者ADR报告为样本数据,采用粗糙集方法确定ADR风险评价指标及权重。从用药人群和临床用药两个角度,设计7个二级指标并计算出对应的权重系数,最终得到精神障碍用药ADR风险评价指标体系。综合研究表明,利用粗糙集构建的ADR风险指标体系能够有效地避免主观确定指标权重的问题,为今后合理用药和ADR风险评价提供一个新的方向和途径。
To construct the risk evaluation system for adverse drug reaction(ADR)of drugs for mental disorders,a new method based on rough set theory for the risk evaluation index of ADR was put forward.The ADR reports of patients with mental disorders from January 2012 to June 2019 in a hospital were taken as sample data and the quantitative statistics were used to determine the ADR risk assessment indicators and weights.Seven secondary indicators were set from the medication population and clinical medi-cation,and the corresponding weight coefficients were calculated to construct an ADR evaluation index system for medications for mental disorders.ADR risk evaluation index system for mental disorders medication is constructed.Finally the ADR risk evaluation index system of mental disorders was obtained.This method provides a new direction and means for rational medication use and risk assessment of ADR in the future.
作者
王培培
叶明全
童九翠
WANG Pei-pei;YE Ming-quan;TONG Jiu-cui(School of Medical Information,Wannan Medical College,Wuhu Anhui,241002;Research Center of Health Big Data Mining and Applications,Wannan Medical College,Wuhu Anhui,241002;Department of Clinical Medicine of Yijishan Hospital,Wannan Medical College,Wuhu Anhui,241001)
出处
《山西大同大学学报（自然科学版）》
2021年第3期52-55,60,共5页
Journal of Shanxi Datong University(Natural Science Edition)
基金
教育部人文社会科学研究规划基金“健康大数据下药品不良反应风险评价与预警研究”[16YJAZH071]
国家自然科学基金“基于粒计算的脑核磁共振图像分割研究”[61672386]
安徽省自然科学基金“基于表观遗传学探讨豆腐果苷对抑郁大鼠模型的抗抑郁作用机制”[1808085MH290]
皖南医学院中青年科研基金“基于基因表达数据对左右两侧乳腺癌患者致病基因的对比分析研究”[WK201921]。
