摘要
目的探讨葡萄球菌烫伤样皮肤综合征(SSSS)患儿γ球蛋白、CD_(64)指数、α1球蛋白表达与临床疗效的关系。方法选取2017年1月-2019年1月河北北方学院附属第一医院收治的59例SSSS患儿作为研究组,其中15例急性发作期,44例临床缓解期,同期选取51例特应性皮炎患儿作为对照组。统计两组及研究组不同发作期患儿、不同临床疗效、有无复发患儿γ球蛋白、CD_(64)指数、α1球蛋白水平,分析血各指标单一及联合诊断SSSS价值及其与临床疗效、复发的关系。结果研究组γ球蛋白(26.34±7.91)%、CD_(64)指数(2.15±0.64)、α1球蛋白(4.71±1.42)%表达水平均高于对照组患儿(P<0.05);研究组急性发作期γ球蛋白、CD_(64)指数、α1球蛋白高于临床缓解期患儿(P<0.05);γ球蛋白、CD_(64)指数、α1球蛋白联合检测诊断SSSS的曲线下面积(AUC)大于单一指标;治疗后研究组有效、无复发患儿γ球蛋白、CD_(64)指数、α1球蛋白低于研究组无效、复发患儿(P<0.05)。结论γ球蛋白、CD_(64)指数、α1球蛋白高表达与SSSS患儿病情程度存在一定相关性,早期联合检测上述指标水平,可为临床诊治、疗效评估、预后判断提供有效辅助手段。
OBJECTIVE To explore the relationship betweenγglobulin,CD_(64)index,α1 globulin expression and clinical efficacy in children with staphylococcal scalded skin syndrome(SSSS).METHODS A total of 59 children with SSSS who were treated in the First Affiliated Hospital of Hebei North University from Jan 2017 to Jan 2019 were assigned as the study group,15 of whom were at acute attack period,and 44 were at clinical remission period;meanwhile,51 children with atopic dermatitis were set as the control group.The levels ofγglobulin,CD_(64)index andα1 globulin of the two groups of children and the children at different attack periods,the children with different clinical efficacies and children with or without recurrence in the study group were statistically analyzed,and the values of single blood index and joint detection of the blood indexes in diagnosis of SSSS and their relationship with clinical efficacy and recurrence were observed.RESULTS The levels ofγglobulin,CD_(64)index andα1 globulin of the study group were respectively(26.34±7.91)%,(2.15±0.64)and(4.71±1.42)%,significantly higher than those of the control group(P<0.05).The area under curve(AUC)of the joint detection ofγglobulin,CD_(64)index andα1 globulin was larger than that of the single index in diagnosis of SSSS.In the study group,the levels ofγglobulin,CD_(64)index andα1 globulin of the children without recurrence were significantly lower than those of the children with recurrence after the treatment(P<0.05).CONCLUSION The higher expression ofγglobulin,CD_(64)index andα1 globulin shows certain association with the illness condition of the children with SSSS,and the joint detection of the above indexes in early stage can serve as an auxiliary mean for clinical diagnosis and treatment,assessment of clinical effect and prediction of prognosis.
作者
李文斌
王艳飞
魏阿平
高娇娇
曹燕玲
马文霞
LI Wen-bin;WANG Yan-fei;WEI A-ping;GAO Jiao-jiao;CAO Yan-ling;MA Wen-xia(The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2021年第9期1436-1440,共5页
Chinese Journal of Nosocomiology
基金
河北省卫健委医学科学研究基金资助项目(20200554)。
