摘要
目的探析甲巯咪唑联合清热消瘿汤加减对甲状腺功能亢进(甲亢)患者甲功五项水平的影响。方法选择2019年1月—2020年5月本院收治的132例甲亢患者作为研究对象,随机分为研究组与对照组两组,每组各66例。对照组给予甲巯咪唑治疗,研究组在对照组基础之上联合清热消瘿汤治疗。分析治疗3个月后两组患者临床疗效差异,观察治疗前与治疗3个月后,两组患者中医症状积分(颈前肿大、目胀多泪、烦躁易怒)及甲状腺功能指标[甲状腺素(T_(4))、三碘甲状原氨酸(T_(3))、甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)、促甲状腺激素(TSH)]水平变化,并分析比较治疗3个月内,两组患者药物不良反应发生率。结果研究组患者治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);两组患者治疗后颈前肿大、目胀多泪、烦躁易怒各项积分明显低于治疗前,差异有统计学意义(P<0.05);研究组患者颈前肿大、目胀多泪、烦躁易怒各项积分明显低于对照组,差异有统计学意义(P<0.05);两组患者治疗后T_(4)、T_(3)、TGAb、TMAb水平明显低于治疗前,差异有统计学意义(P<0.05);研究组患者T_(4)、T_(3)、TGAb、TMAb水平明显低于对照组,差异有统计学意义(P<0.05);两组患者治疗后TSH水平明显高于治疗前,差异有统计学意义(P<0.05);且研究组患者TSH水平明显高于对照组,差异有统计学意义(P<0.05);研究组患者药物不良反应总发生率明显低于对照组,差异有统计学意义(P<0.05)。结论甲巯咪唑联合清热消瘿汤加减可有效治疗甲亢,改善患者症状及甲状腺功能,且安全性良好。
Objective To explore the effects of methimazole combined with qingrexiaoying decoction or not on levels of five thyroid function indicators in patients with hyperthyroidism.Methods 132 cases of hyperthyroidism patients admitted to our hospital from January 2019 to May 2020 were selected as the research object,and they were randomly divided into two groups:study group and control group,66 cases in each group.Methimazole was given to the control group,while methimazole combined with qingrexiaoying decoction was given to patients in the study group.Three months after treatment,the clinical curative effects of the two groups were analyzed,the changes of Chinese medicinesymptom integral(swelling of the anterior portion,eyes get puffy and hyperdacryosis,anxiety andirritability)and thyroid function index[thyroxine(T_(4)),three iodine thyroid glycine(T_(3))and thyroglobulin antibody(TGAb),thyroid microsomal antibody(TMAb),thyroid stimulating hormone(TSH)]level were observed,the incidence of adverse drug reactions within 3 months of the two groups were analyzed and compared.Results The total effective rate in the study group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,the scores of anterior neck enlargement,eye distention and hyperdacryosis,anxiety and irritability in both 2 groups were significantly lower than those before treatment,with statistical significance(P<0.05).The scores of the Chinese medicinesymptom in the study group were significantly lower than those in the control group,with statistical significance(P<0.05).The levels of T_(4),T_(3),TGAb and TMAB in 2 groups after treatment were significantly lower than those before treatment,with statistical significance(P<0.05).The levels of T_(4),T_(3),TGAb and TMAB in the study group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).The level of TSH in 2 groups after treatment was significantly higher than that before treatment,the difference was statistically significant(P<0.05).The TSH level in the study group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).The total incidence of ADR in the study group was significantly lower than that in the control group,with statistical significance(P<0.05).Conclusions Methimazole combined with qingrexiaoying decoction or not could effectively treat hyperthyroidism,improve the symptoms and thyroid function of patients,with good safety.
作者
郑建勋
ZHENG Jian-xun(The first people's hospital of Ruzhou city,Ruzhou,Henan,467599,China)
出处
《齐齐哈尔医学院学报》
2021年第8期686-689,共4页
Journal of Qiqihar Medical University
