摘要
目的:探讨老年2型糖尿病(T2DM)患者血清脂肪因子血管生成素样蛋白4(ANGPTL4)、促代谢因子(Betatrophin)、腹腔脂肪型丝氨酸蛋白酶抑制剂(Vaspin)水平与血糖、血脂、下肢血管病变(LVD)的关系。方法:选取我院2018年8月2019年8月收治的老年T2DM患者108例,根据患者是否合并LVD,分成LVD组(n=38)和无LVD组(n=70),比较两组临床资料、血清ANGPTL4、Betatrophin、Vaspin水平、血糖指标[空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)]、血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]。经Pearson线性相关分析患者血清ANGPTL4、Betatrophin、Vaspin水平与血糖、血脂指标相关性。经Logistic多因素回归模型分析患者LVD发生的影响因素。结果:LVD组舒张压、收缩压均高于无LVD组(P<0.05)。LVD组血清Betatrophin水平及TC、TG、LDL-C、FPG、2hPG、HbA1c高于无LVD组,血清ANGPTL4、Vaspin水平及HDL-C低于无LVD组(P<0.05)。Pearson线性相关分析显示,血清ANGPTL4、Vaspin与TC、TG、LDL-C、FPG、2hPG、HbA1c呈负相关,与HDL-C呈正相关(P<0.05)。血清Betatrophin与TC、TG、LDL-C、FPG、2hPG、HbA1c呈正相关,与HDL-C呈负相关(P<0.05)。Logistic多因素回归模型分析结果显示,血清ANGPTL4、Betatrophin、Vaspin以及舒张压、TC、TG、HDL-C、LDL-C、FPG、2hPG、HbA1c是患者LVD发生的影响因素(P<0.05)。结论:老年T2DM合并LVD患者的血清ANGPTL4、Vaspin水平明显下降,而血清Betatrophin水平升高,且三者与血糖、血脂指标均存在相关性,并且是患者发生LVD的影响因素,临床可考虑通过检测血清ANGPTL4、Betatrophin、Vaspin水平,辅助评估LVD的发生风险。
Objective:To explore the relationship between serum angiopoietin-like 4(ANGPTL4),Betatrophin(Betatrophin)and Vaspin(Vaspin)levels and blood glucose,blood lipids and lower limb vascular disease(LVD)in elderly patients with type 2 diabetes(T2DM).Methods:A total of 108 elderly patients with T2DM who were admitted to our hospital from August 2018 to August 2019 were selected,and divided into LVD group(n=38)and non LVD group(n=70)according to whether the patients had LVD.The clinical data,serum ANGPTL4,Betatrophin,Vaspin levels,blood glucose indicators[fasting plasma glucose(FPG),2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c)],blood lipid indicators[total cholesterol(TC),triglycerides(TG)],high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]of the two groups were compared.Pearson linear correlation analysis was used to analyze the correlation between serum ANGPTL4,Betatrophin,Vaspin levels and blood glucose and blood lipid indicators.Logistic multivariate regression model was used to analyze the influencing factors of LVD.Results:The diastolic blood pressure and systolic blood pressure of the LVD group were higher than those of the non LVD group(P<0.05).Serum Betatrophin levels and TC,TG,LDL-C,FPG,2 hPG,HbA1c of LVD group were higher than those of non LVD group,and serum ANGPTL4,Vaspin levels and HDL-C were lower than those of non LVD group(P<0.05).Pearson linear correlation analysis showed that serum ANGPTL4 and Vaspin were negatively correlated with TC,TG,LDL-C,FPG,2 hPG,HbA1c,and positively correlated with HDL-C(P<0.05).Serum Betatrophin were positively correlated with TC,TG,LDL-C,FPG,2 hPG and HbA1c,and negatively correlated with HDL-C(P<0.05).Logistic multivariate regression model analysis showed that serum ANGPTL4,Betatrophin,Vaspin and diastolic blood pressure,TC,TG,HDL-C,LDL-C,FPG,2 hPG,HbA1c were the influencing factors of LVD in patients(P<0.05).Conclusion:The serum ANGPTL4 and Vaspin levels of elderly patients with T2DM combined with LVD are decreased significantly,while the serum Betatrophin levels are increased.And the three indicators are correlated with blood glucose and blood lipid indicators,and they are the influencing factors of patients with LVD.Clinically,the serum ANGPTL4,Betatrophin and Vaspin levels can be examined to assist in the assessment of the risk of LVD.
作者
罗悦玲
黄彬
曹聪
韦丽芳
黄正壮
LUO Yue-ling;HUANG Bin;CAO Cong;WEI Li-fang;HUANG Zheng-zhuang(Department of General Medicine,Affiliated Hospital of Youjiang Medical College for Nationalities,Baise,Guangxi,533000,China;Medical Examination Center,Affiliated Hospital of Youjiang Medical College for Nationalities,Baise,Guangxi,533000,China;Department of Critical Care Medicine,Nanning First People's Hospital/The Fifth Affiliated People's Hospital of Guangxi Medical University,Nanning,Guangxi,530022,China)
出处
《现代生物医学进展》
CAS
2021年第10期1863-1867,1853,共6页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81160146)。
