摘要
黄嘌呤氧化酶(xanthine oxidase, XOD)参与体内嘌呤的代谢,是尿酸(uric acid, UA)生成的关键酶,成为临床治疗高尿酸血症的重要靶点。抑制XOD对治疗痛风等高尿酸血症相关的疾病以及组织氧化损伤具有重要作用。本文对具有XOD抑制作用的天然产物的研究进展进行综述。
Xanthine oxidase(XOD),catalyzing purine metabolism,is the key enzyme in uric acid(UA)biosynthesis,and becomes an important target for hyperuricemia treatment.The inhibition on XOD plays an important role in the treatment of hyperuricemia-related diseases,such as gout,as well as oxidative stress-induced tissue injury.Here,studies on the natural products with XOD inhibition are reviewed.
作者
姜楠
张晓琳
田金英
叶菲
JIANG Nan;ZHANG Xiao-lin;TIAN Jin-ying;YE Fei(Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050,China)
出处
《药学学报》
CAS
CSCD
北大核心
2021年第5期1229-1237,共9页
Acta Pharmaceutica Sinica
基金
国家“重大新药创制”科技重大专项(2018ZX09711001-003-005)
国家自然科学基金青年基金项目(81600546,82000820)
中国医学科学院医学与健康科技创新工程团队项目(CIFMS-2016-I2M-3-012)。
