摘要
目的探讨健康孕妇血脂水平的变化特点及其合适水平。方法选取健康孕妇2124名,按孕周分为早孕组(276名)、中孕组(961名)及晚孕组(887名),按年龄不同分为适龄组(1646名)及超龄组(478名),以健康非孕妇女712名作为对照组。检测所有对象的三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(apo A1)和载脂蛋白B(apo B)。采用百分位数法[第2.5百分位数(P_(2.5))和第97.5百分位数(P_(97.5))]确定妊娠妇女血脂项目的合适水平。结果除早孕组TG水平外,不同孕期各组TC、HDL-C、LDL-C、apo A1及apo B水平均高于对照组(P<0.05)。中孕组及晚孕组各项血脂指标均高于早孕组(P<0.05);晚孕组各项血脂指标均高于中孕组(P<0.05)。采用百分位数法确定与孕期相关的TC、HDL-C、LDL-C、apo A1及apo B的合适水平,以及与孕周、年龄相关的TG的合适水平。结论确定了郑州地区健康孕妇血脂项目的合适水平,对可为临床监测不同孕期孕妇的血脂状况提供参考。
Objective To investigate the changes of blood lipid levels among healthy pregnant women,and to define appropriate blood lipid levels for healthy pregnant women.Methods A total of 2124 healthy pregnant women were enrolled,which were classified into 3 groups according to gestational weeks,including early pregnancy group(276 cases),middle pregnancy group(961 cases)and late pregnancy group(887 cases).All the subjects were classified into 2 groups according to ages,including advanced age group(478 cases)and appropriate age group(1646 cases).A total of 712 non-pregnant women were enrolled as control group.The levels of triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A1(apo A1)and apolipoprotein B(apo B)were determined.The appropriate blood lipid levels for healthy pregnant women were defined by percentile mothod[the 2.5th percentile(P_(2.5))and the 97.5th percentile(P_(97.5))].Results Except for TG in early pregnancy group,the other blood lipid parameters in early,middle and late pregnancy groups were higher than those in control group(P<0.05).All the blood lipid parameters in middle and late pregnancy groups were higher than those in early pregnancy group(P<0.05).All the blood lipid parameters in late pregnancy group were higher than those in middle pregnancy group(P<0.05).Gestational week-specific appropriate blood lipid levels of TC,HDL-C,LDL-C,apo A1 and apo B had been defined by percentile method.Gestational week-specific and age-specific appropriate levels of TG had been also defined by percentile method.Conclusions Appropriate blood lipid levels of healthy pregnant women in Zhengzhou have been defined,in order to provide a reference for monitoring blood lipid levels during pregnancy.
作者
代延朋
袁恩武
刘军杰
李玉山
王全先
DAI Yanpeng;YUAN Enwu;LIU Junjie;LI Yushan;WANG Quanxian(Department of Clinical Laboratory,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China;Human Sperm Bank,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China)
出处
《检验医学》
CAS
2021年第6期604-608,共5页
Laboratory Medicine
基金
河南省高等学校重点科研项目(16B320024)。
关键词
血脂
合适水平
妊娠
孕周
Blood lipid
Appropriate level
Pregnancy
Gestational week
