摘要
The severe acute respiratory syndrome COVID-19 was discovered on December 31,2019 in China.Subsequently,many COVID-19 cases were reported in many other countries.However,some positive COVID-19 samples had been reported earlier than those officially accepted by health authorities in other countries,such as France and Italy.Thus,it is of great importance to determine the place where SARS-CoV-2 was first transmitted to human.To this end,we analyze genomes of SARS-CoV-2 using k-mer natural vector method and compare the similarities of global SARS-CoV-2 genomes by a new natural metric.Because it is commonly accepted that SARS-CoV-2 is originated from bat coronavirus RaTG13,we only need to determine which SARS-CoV-2 genome sequence has the closest distance to bat coronavirus RaTG13 under our natural metric.From our analysis,SARS-CoV-2 most likely has already existed in other countries such as France,India,Netherland,England and United States before the outbreak at Wuhan,China.
作者
Shaojun PEI
Stephen S-TYAU
裴少君;丘成栋(Department of Mathematical Sciences,Tsinghua University,Beijing 100084,China;Yanqi Lake Beijing Institute of Mathematical Sciences and Applications,Beijing 101408,China)
基金
supported by Tsinghua University Spring Breeze Fund(2020Z99CFY044)
Tsinghua University start-up fund
Tsinghua University Education Foundation fund(042202008)。
