摘要
目的:探究金水六君煎辅助治疗对稳定期慢性阻塞性肺疾病(COPD)患者肺功能和免疫功能的影响。方法:选取2015年1月至2018年6月江苏省苏北人民医院收治的稳定期COPD患者160例作为研究对象,随机分为观察组和对照组,每组80例。对照组采用常规西药治疗,观察组在对照组基础上加服金水六君煎。比较2组患者治疗前后肺功能、免疫功能、免疫球蛋白以及临床有效率。结果:治疗后观察组临床有效率为86.25%,显著高于对照组68.75%(P<0.05)。治疗后2组免疫球蛋白(IgA、IgG和IgM)、肺功能(FEV1、FEV1和FEV1/FVC)、免疫功能(CD4^(+)、Th17和Th17/Treg)较治疗前明显提高(P<0.05),且观察组上述指标治疗后均高于对照组(P<0.05)。治疗后2组CD8^(+)较治疗前降低(P<0.05),且观察组CD8^(+)低于对照组(P<0.05)。结论:相较于常规的西药,加服金水六君煎治疗稳定期COPD能够显著改善患者呼吸功能,具有更好的疗效,可能与该方剂对免疫细胞及其细胞因子的作用有关。
Objective:To explore the effects on lung function and immune function in patients with stable chronic obstructive pulmonary disease(COPD)by using Jinshui Liujun Decoction combined with Western medicine.Methods:A total of 160 patients with stable COPD admitted to the Department of Geriatrics of our hospital from January 2015 to June 2018 were selected as the research objects,and were randomly divided into an observatin group and a control group,with 80 cases in each group.The control group was treated with conventional Western medicine,while the combined Jinshui Liujun Decoction group was treated with Jinshui Liujun Decoction on the basis of the routine group.The lung function,immune function,immunoglobulin and clinical effectiveness were compared between the 2 groups.Results:After treatment,the clinical effective rate of the observation group was 86.25%,which was significantly higher than the clinical effective rate of the control group(68.75%)(P<0.05).After treatment,the 2 groups of immunoglobulin(IgA,IgG and IgM),lung function(FEV1,FEV1 and FEV1/FVC),immune function(CD4^(+),Th17 and Th17/Treg)were significantly improved compared to those before treatment(P<0.05).The above indicators in the observation group were higher than those in the control group after treatment(P<0.05).After treatment,the CD8^(+)of the 2 groups was lower than that before treatment(P<0.05),and the CD8^(+)of the observation group was lower than that of the control group(P<0.05).Conclusion:Compared with conventional Western medicine,the addition of Jinshui Liujun Decoction in the treatment of stable COPD can significantly improve the respiratory function of patients with better curative effect,which may be related to the effect of the prescription on immune cells and their cytokines.
作者
陈林晖
王海鹏
于祥
陈慧
张旭东
CHEN Linhui;WANG Haipeng;YU Xiang;CHEN Hui;ZHANG Xudong(Department of Geriatrics,Subei People′s Hospital,Jiangsu Province,Yangzhou 225001,China;Department of Gastroenterology,North District Hospital,Subei People′s Hospital of Jiangsu Provine,Yangzhou 225001,China)
出处
《世界中医药》
CAS
2021年第9期1450-1453,1458,共5页
World Chinese Medicine
基金
江苏省自然科学基金项目(BK20191218)。
关键词
稳定期
慢性阻塞性肺疾病
金水六君煎
肺功能
免疫功能
免疫球蛋白
第1秒钟用力肺活量
疗效
Stable period
Chronic obstructive pulmonary disease
Jinshui Liujun fried
Lung function
Immune function
Immunoglobulin
Forced vital capacity in the first second
Therapeutic effect
