摘要
目的探讨尿中金属水平与高血压之间关系,为居民高血压防控提供依据。方法于2014年9月—2015年6月采用多阶段分层整群抽样方法调查安徽省沿江地区居民2314人,其中男性1073人(46.4%),女性1241人(53.6%),18~59岁居民1609人,≥60岁居民705人。尿中镉检测采用石墨炉原子吸收光谱法,尿铬、铜、铁、锰、锌、砷及铅检测采用电感耦合等离子体发射光谱仪法。结果2314名成年居民中高血压患者716例,患病率为30.94%。肌酐校正后,高血压组居民尿液铬、铜、铁、锰、锌及铅元素含量高于非高血压组居民(P<0.05)。多因素非条件logistic回归分析结果显示,尿铁含量越高,高血压患病风险越大(OR=1.448,95%CI=1.079~1.944);尿镉含量越高,高血压患病风险越大(OR=1.353,95%CI=1.022~1.792);尿中铅水平增加,高血压患病风险增加(OR=1.659,95%CI=1.224~2.249)。结论尿中铁、镉、铅浓度较高可能会增加居民患高血压风险。
Objective To investigate the relationship between urinary metals and hypertension in residents for providing evidences to hypertension prevention and control in the residents.Methods Using stratified multistage cluster sampling,we recruited 2314 residents aged 18 years and above in regions along the Yangzi River in Anhui province and conducted questionnaire surveys,physical examination and laboratory detections among the residents from September 2014 to June2015.Cadmium in urine samples collected from the residents was detected with graphite furnace atomic absorption spectrometry;while chromium,copper,iron,manganese,zinc,arsenic,and lead in the urine samples were detected with inductively coupled plasma emission spectrometer.Results Of the residents surveyed,1073(46.4%)were male and 1241(53.6%)were female;1609 were aged 18–59 years and 705 aged≥60 years.Among the residents,totally 716 hypertension patients were identified and the hypertension prevalence rate was 30.94%.After creatinine correction,the contents of chromium,copper,iron,manganese,zinc and lead in urine samples of residents with hypertension were significantly higher than those in urine samples of residents without hypertension(all P<0.05).The results of unconditional multivariate logistic regression analysis demonstrated that urinary iron was positively correlated with an increased hypertension risk(odds ratio[OR]=1.448,95%confidence interval[95%CI]:1.079–1.944);urinary cadmium and lead were also positively correlated with increased hypertension risk with the OR of 1.353(95%CI:1.022–1.792)and 1.659(95%CI:1.224–2.249),respectively.Conclusion High urinary iron,cadmium and lead may predicate increased risk of hypertension among adult residents in regions along the Yangzi River in Anhui province.
作者
杨婉君
钟琦
吴华兵
秦其荣
冯晓明
黄芬
YANG Wan-jun;ZHONG Qi;WU Hua-bing(School of Public Health,Anhui Medical University,Hefei,Anhui Province 230032,China)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2021年第5期807-811,共5页
Chinese Journal of Public Health
基金
2019年度高校学科(专业)拔尖人才学术资助项目(gxbjZD09)。
关键词
安徽
沿江地区
尿液
金属元素
高血压
Anhui province
area along the Yangtze River
urine
metallic element
hypertension
