摘要
MYCT1基因是近年在喉癌中发现的一种新基因,其在多种正常组织中表达,在多种恶性肿瘤中表达具有明显差异,可以调控肿瘤细胞的增殖、凋亡、迁移等生物学功能,从而参与肿瘤的发展进程。MYCT1在多种恶性肿瘤中显示抑癌基因作用,而在胃癌、急性髓系白血病中的作用尚存在争议。多种转录因子、微RNA和CpG岛甲基化参与MYCT1调控肿瘤的过程。未来应深入研究MYCT1在肿瘤中涉及的信号通路,明确上下游靶基因,了解其对不同肿瘤患者生存及预后的影响,探索MYCT1成为新的肿瘤治疗靶点的可能性和潜在价值。
Myc target 1(MYCT1)is a newly discovered gene in laryngeal cancer in recent years.It is expressed in a variety of normal tissues and is differentially expressed in a variety of malignant tumors.It can regulate the proliferation,apoptosis,migration and other biological functions of tumor cells,thus participate in the development of tumor.MYCT1 has been shown to act as a tumor suppressor in a variety of malignancies,but its role in gastric cancer and acute myeloid leukemia is still controversial.Various transcription factors,microRNAs and CpG island methylation are involved in MYCT1 regulation of tumor.In the future,the signaling pathways involving MYCT1 in tumors should be further studied,to identify the upstream and downstream target genes and understand the influence of MYCT1 on the survival and prognosis of patients with different tumors,and further explore the possibility and potential value of MYCT1 as a new tumor therapeutic target.
作者
张晶
刘晓红
ZHANG Jing;LIU Xiaohong(Department of Pathology,Shandong Provincial Third Hospital,Jinan 250031,China;Department of Pathology,960 th Hospital of the PLA Jonit Support Force,Jinan 250031,China)
出处
《医学综述》
CAS
2021年第11期2140-2144,共5页
Medical Recapitulate
基金
国家自然科学基金(81172261)。
