摘要
目的探索CombretastatinA-4(CA-4)类似物YK-3-250对人前列腺癌细胞裸鼠移植瘤生长的影响。方法将成功构建的LNCaP细胞裸鼠移植瘤模型随机分为对照组和治疗组(A组和B组),分别腹腔注射磷酸盐缓冲液(PBS)、YK-3-250溶液15 mg/kg、30 mg/kg,每周两次,干预4周。比较各组移植瘤体积、质量及抑瘤率。结果两组移植瘤体积、质量及抑瘤率比较,差异有统计学意义(P<0.05);B组移植瘤给药后体积、质量低于A组,抑瘤率高于A组(P<0.05)。结论 CA-4类似物YK-3-250对人前列腺癌细胞裸鼠移植瘤有较好的抑制作用,且这种抑制作用具有剂量依赖性。
Objective To investigate the effect of YK-3-250,a class of CombretastatinA-4(CA-4)analogs,on the growth of human prostate cancer xenografts in nude mice.Methods The successfully constructed LNCaP cell nude mouse xenograft tumor model was randomly divided into control group(group A)and treatment group(group B).Group A got intraperitoneal injection of phosphate buffered saline(PBS)15 mg/kg,group B got intraperitoneal injection of YK-3-250 solution 30 mg/kg,twice a week for 4 weeks.The tumor volume,tumor mass and tumor inhibition rate of each group were compared.Results The comparison of tumor volume,tumor mass and tumor inhibition rate of between the two groups was with P<0.05.,The volume and mass of transplanted tumors in group B were lower than those in group A,and the tumor inhibition rate was higher than that in group A(P<0.05).Conclusion YK-3-250 can effectively inhibit the growth of human prostate cancer xenografts in nude mice,and this inhibition effect has dose-dependent.
作者
王健明
王兆刚
刘杰
谭善峰
张维颉
李春建
WANG Jianming;WANG Zhaogang;LIU Jie;TAN Shanfeng;ZHANG Weijie;LI Chunjian(The People’s Hospital of Linyi,Linyi 276000;Postgraduate department of Shandong First Medical University<Shandong Academy of Medical Sciences>,Taian 271016;Shandong Medical College,Linyi 276003,Shandong)
出处
《菏泽医学专科学校学报》
2021年第2期1-2,71,共3页
Journal of Heze Medical College
基金
山东省医药卫生科技发展计划项目(2016WS0232)。
关键词
前列腺癌
移植瘤
CA-4类似物
Prostate cancer
Xenografts
CombretastatinA-4 analogs
