摘要
(2R,3R)-1,4-二甲氧基-1,1,4,4-四苯基-2,3-丁二醇是一类应用广泛的手性二醇,本文从绿色化学的角度综述了其合成方法的研究进展。本课题组通过(2R,3R)-1,1,4,4-四苯基丁四醇的区域选择性反应设计新的合成方案,缩短了合成路线,用常规试剂如甲醇、氯化亚砜和无机碱液等取代了DDQ(2,3-二氯-5,6-二氰-1,4-苯)、LiAlH4、NaH和MeI等化学试剂,发展出高效、便捷、绿色化程度较高的合成方案。
(2 R,3 R)-1,4-dimethoxy-1,1,4,4-tetraphenylbutane-2,3-diol has diverse applications in asymmetric organic synthesis,and this paper briefly introduces the progress on its synthetic methods from the perspective of green chemistry.Our group developed new synthetic methods based on the region-selective transformation of(2 R,3 R)-1,1,4,4-tetraphenylbutanetetraol.In the preparation,methanol was used as a methylating reagent and common inorganic alkali liquor was used instead of DDQ and LiAlH4.
作者
胡晓允
单自兴
Xiaoyun Hu;Zixing Shan(College of Chemistry and Materials Science,South-Central University for Nationalities,Wuhan 430074,China;College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China)
出处
《大学化学》
CAS
2021年第4期129-134,共6页
University Chemistry
基金
国家自然科学基金(21302233)
中央高校基本科研业务费专项资金项目(CZY20016)。
