摘要
以α-(1,2-亚乙基)酰胺和端炔发生[4+1]环合反应,高效合成了一系列螺环类吡咯啉-2-酮类化合物,其结构经^(1)H NMR,^(13)C NMR和HR-MS(ESI)表征,并对该反应机理进行了探讨。该合成方法具有底物适用范围广泛,操作简单,条件温和以及收率高等优点。
A series of spirocyclic pyrroline-2-one compounds were obtained via[4+1]annulation ofα-(1,2-ethylene)amides and terminal alkynes,and the structures of target compounds were characterized by ^(1)H NMR,^(13)C NMR and HR-MS(ESI).Moreover,a mechanism for the reaction was proposed.The synthetic method has the advantages of extensive substrates,simple operation,mild conditions and high yield.
作者
任传清
季晓晖
季建伟
张强
宋娟
REN Chuan-qing;JI Xiao-hui;JI Jian-wei;ZHANG Qiang;SONG Juan(Shaanxi Key laboratory of Catalysis, School of Chemical & Environmental Science, Shaanxi University of Technology, Hanzhong 723000, China)
出处
《合成化学》
CAS
2021年第5期430-434,共5页
Chinese Journal of Synthetic Chemistry
基金
陕西省科技厅自然科学基础研究计划项目(2020JM-602)
陕西省教育厅基金资助项目(19JS011)
陕西理工大学人才启动项目(SLGKYQD2-12)。
