摘要
目的评估肿瘤患者中高尿酸血症的发生情况及其相关临床特征。方法回顾性分析2018年4月至2020年8月期间在江苏大学附属医院化疗科住院的所有肿瘤患者及其中合并高尿酸血症患者。分析高尿酸血症肿瘤患者的肿瘤类型、TNM分期及转移部位。结果3116例肿瘤患者中合并高尿酸血症患者188例(6.03%),男性患病率为8.81%(147/1669),明显高于女性的患病率2.83%(41/1447),差异具有统计学意义(P<0.05)。肿瘤患者合并高尿酸血症比例最高的是依次是声带癌、上颚癌、下咽癌和膀胱癌(33.33%)、肝癌(14.71%)、卵巢癌(10.92%)。合并高尿酸血症患者比例非常低的是宫颈癌(1.75%)、胰腺癌(1.82%)、乳腺癌(2.51%)和子宫内膜癌癌(3.57%)。合并高尿酸血症的肿瘤患者TNM分期以Ⅳ期患者最多(124例,65.9%),Ⅰ期、Ⅱ期、Ⅱ期患者分别为15例、24例和25例。合并高尿酸血症的食管癌患者发生淋巴结转移率最高(64.3%),肺癌发生骨转移率最高(27.3%)及脑转移率最高(18.2%),大肠癌发生肝转移率最高(43.9%),妇科肿瘤发生腹盆腔转移率最高(50.0%),乳腺癌发生肺转移率最高(33.3%)。结论不同肿瘤类型中高尿酸血症的患病率存在明显差异,卵巢癌患者合并高尿酸血症患者的比例高于乳腺癌患者。高尿酸血症更多见于男性肿瘤患者及晚期肿瘤患者,可能与恶性肿瘤患者的预后有关。
Objective To evaluate the incidence of hyperuricemia in patients with cancer and its clinical characteristics.Methods The clinical data of the cancer patients in the Affiliated Hospital of Jiangsu University from April 2018 to August 2020 were analyzed retrospectively.The tumor type,TNM stage and metastasis site of the cancer patients with hyperuricemia were analyzed.Results Among 3116 patients with cancer,188(6.03%)cases were complicated with hyperuricemia.The prevalence rate of male was 8.81%(147/1669),which was significantly higher than that of female 2.83%(41/1447),the difference was statistically significant(P<0.05).The proportion of patients with hyperuricemia arranged from high to low as vocal cord cancer,maxillary cancer,hypopharyngeal cancer and bladder cancer(33.33%),liver cancer(14.71%)and ovarian cancer(10.92%).The proportion of patients with hyperuricemia was low in cervical cancer(1.75%),pancreatic cancer(1.82%),breast cancer(2.51%)and endometrial cancer(3.57%).The TNM stage of patients with hyperuricemia was the most in stageⅣ(124 cases,65.9%),15 cases in stageⅠ,24 cases in stageⅡand 25 cases in stageⅢ.The patients with hyperuricemia had the highest rate of lymph node metastasis(64.3%)in esophagus cancer.The highest rate of bone metastasis(27.3%)and brain metastasis(18.2%)occurred in the patients with lung cancer.The highest rate of liver metastasis(43.9%)occurred in the patients with colorectal cancer.The highest rate of abdominal and pelvic metastasis(50.0%)occurred in the cases of gynecological cancer.And the highest rate of lung metastasis(33.3%)occurred in the cases of breast cancer.Conclusions Hyperuricemia is more common in male cancer patients and patients with advanced cancer,which may be related to the prognosis of patients with malignant tumor.
作者
庄秀芬
向敏
孙闻
石林
李小琴
胡筱
ZHUANG Xiufen;XIANG Min;SUN Wen;SHI Lin;LI Xiaoqin;HU Xiao(Department of Oncology, the Affiliated Hospital of Jiangsu University, Zhenjiang 212050,China;Department of Clinical Laboratory, the Affiliated Hospital of Jiangsu University, Zhenjiang 212050,China;Department of Oncology, Jiangsu Cancer Hospital, Nanjing 210009,China;Department of Oncology, Suqian First Hospital, Suqian 223800,China)
出处
《中国肿瘤外科杂志》
CAS
2021年第3期272-277,共6页
Chinese Journal of Surgical Oncology
基金
国家自然科学基金(81402442)。
