摘要
在心脑血管疾病的发生发展中,脑心之间生理病理关系紧密,临床病证相互影响,病理机制复杂。临床研究表明,脑部疾病如卒中多并发心脏疾病,心脏疾病如心心房颤动动也会引发脑部疾病,甚至加重患者脑萎缩,出现认知障碍等。中医也认为"神明之体藏于脑,神明之用发于心",元神在脑,识神在心,心脑息息相关。脑之神明伤,累及于心,心之神明伤,累及于脑。因此,脑病及心,心病及脑,脑心互损的病理机制成为当今研究的热点之一。该文结合脑心疾病相互影响的临床研究现状,对脑心互损的病理机制进行了总结,从炎症反应、自主神经调节紊乱、细胞凋亡、能量代谢、氧化应激等几个方面的整理和分析,阐述了各种机制的研究概况。在此基础上,根据中医药对脑心功能的认识,以及中医药防治脑心疾病的整体观念,提出需要重视脑心同治的防治理念,并概述了以脑心通胶囊为代表的中医药防治脑心同病的研究进展。该文综述脑心互损的病理机制及其中医药防治的研究现状,将对心脑血管疾病的防治及其深入研究提供参考和借鉴。
The brain and heart has a tight relationship upon physiology and pathology during the development of cardiovascular and cerebrovascular diseases with clinical conditions interacting with each other and complex pathological mechanisms. Clinical studies prove that cerebral diseases such as stroke usually happen with cardiac diseases as complications,and cardiac diseases such as atrial fibrillation can also cause cerebral diseases, which can even aggravate brain atrophy and lead to cognitive impairment. Traditional Chinese medicine(TCM)also believes that"the substance of Shenming is located in the brain and the function in the heart."Specifically,Yuanshen is in the brain and Shishen is in the heart,which thus makes the heart and brain closely related. If Shenming in any of them is impaired,the other one would also be injured. Therefore,the pathological mechanisms of brain-heart mutual damage have become one of the current research hotspots. This paper,combined with the clinical research status of the brain-heart mutual damage,summarized its pathological mechanisms from the perspectives of inflammatory responses,dysregulation of autonomic nervous system,apoptosis,energy metabolism and oxidative stress. The necessity of"brain-heart concurrent regulation"was proposed and the research progress on the treatment of cerebral and cardiac diseases with TCM represented by Naoxintong capsule was profiled in the light of heart and brain function described by TCM and the holistic concept of TCM treating cerebral and cardiac diseases. This paper reviews the pathological mechanisms of brainheart mutual damage and the research progress on its treatment with TCM,which can provide reference for the prevention and treatment of cardiovascular and cerebrovascular diseases and further research on them.
作者
常梦丽
许静
张方博
吴宏伟
唐仕欢
杨洪军
CHANG Meng-li;XU Jing;ZHANG Fang-bo;WU Hong-wei;TANG Shi-huan;YANG Hong-jun(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第12期216-225,共10页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81673700,81973711)
国家重点研发计划项目(2018YFC1704101)
国家“重大新药创制”科技重大专项(2019ZX09201005
2019ZX09721001-005-002)
山东省重点研发计划项目(2017CXGC1301)。
关键词
脑心互损
病理机制
炎症反应
自主神经系统调节紊乱
中医药防治
brain-heart mutual damage
pathological mechanisms
inflammatory responses
dysregulation of autonomic nervous system
prevention and treatment with traditional Chinese medicine
