摘要
目的探讨系统性红斑狼疮(SLE)患者程序性细胞凋亡1(PDCD 1)基因表达与焦虑情绪的相关性。方法以100例SLE患者作为研究对象,采用焦虑自评量表(SAS)评分评估患者的精神状态,运用实时荧光定量PCR法检测患者外周血PDCD 1 mRNA的表达,比较PDCD 1低表达与PDCD 1高表达患者焦虑的发生情况;比较无焦虑、轻度焦虑、中度焦虑以及重度焦虑程度患者外周血PDCD 1基因表达水平;用Logistic回归分析方法评估SLE患者发生焦虑情绪的影响因素。结果PDCD1低表达组患者的焦虑发生率明显高于PDCD 1高表达组,差异有统计学意义(P=0.001);不同焦虑程度患者外周血PDCD 1表达水平比较,无焦虑>轻度>中度及重度焦虑患者、差异有统计学意义(P<0.05),中、重度焦虑患者比较,差异无统计学意义(P>0.05);Logistic回归分析发现,家庭年收入(OR=1.422,95%CI为1.067~1.893)、PDCD 1低表达(OR=2.439,95%CI为1.286~3.153)是SLE患者焦虑发生的危险因素(P<0.05)。结论SLE焦虑患者的PDCD1表达偏低,家庭年收入低、PDCD 1低表达是SLE患者焦虑发生的危险因素。
Objective To investigate the relationship between PDCD 1 expression and the anxiety of patients with systemic lupus erythematosus(SLE).Methods A total of 100 SLE patients were selected.Self-rating anxiety scale(SAS)was used to evaluate emotion state of patients.PDCD 1 mRNA expression level in peripheral blood was detected by real-time fluorescence quantitative PCR(qPCR).The anxiety was compared between SLE patients with low PDCD 1 expression and SLE patients high PDCD 1 expression.PDCD 1 expression levels were compared between the normal,mild anxiety,moderate anxiety and severe anxiety.Logistic regression was used to evaluate the factors which influence the anxiety of SLE patients.Results The anxiety incidence of SLE patients with low PDCD 1 expression was significantly higher than that of SLE patients with high PDCD 1 expression(P=0.001).PDCD1 expression levels in peripheral blood were ranked in the order of no anxiety>mild>moderate and severe anxiety(P<0.05).PDCD 1 expression levels were not significantly different between moderate and severe anxiety(P>0.05).Logistic regression analysis showed that family annual income(OR=1.422,95%CI was 1.067-1.893)and low expression of PDCD1(OR=2.439,95%CI was 1.286-3.153)were the risk factors of anxiety in SLE patients(P<0.05).Conclusion SLE patients with anxiety expressed low PDCD 1.Low family annual income and low expression of PDCD 1 are risk factor of anxiety in SLE patients.
作者
吴双
董海荣
WU Shuang;DONG Hairong(Department of Dermatology,Hohhot First Hospital,Hohhot 010050,Neimongol,China;Department of Science and Education,Hohhot First Hospital,Hohhot 010050,Neimongol,China)
出处
《贵州医科大学学报》
CAS
2021年第6期724-727,共4页
Journal of Guizhou Medical University
基金
内蒙古自治区科学技术厅基金项目(20130423)。
关键词
红斑狼疮
系统性
焦虑
程序性细胞凋亡1基因
相关性分析
lupus erythematosus,systemic(SLE)
anxiety
programmedcelldeath-1(PDCD 1)gene
correlation analysis
