摘要
目的探讨米非司酮的抗早孕机制。方法选取2018年8月至2019年8月本院收治的存在流产需求的早期妊娠患者86例作为研究对象,根据盲抽法分为观察组与对照组,每组43例。对照组采用米非司酮及米索前列醇治疗,在此基础上,观察组加用双炔失碳酯。比较两组流产情况、流产后出血时间、月经恢复时间、孕囊排出时间及不良反应发生率。结果观察组终止妊娠成功率为97.67%,略高于对照组的93.02%,但差异无统计学意义。两组月经恢复时间及孕囊排出时间比较差异无统计学意义;观察组流产后出血时间明显短于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论米非司酮的抗早孕效果较好,但流产后出血时间较长,需配合其他药物,以增强药物流产安全性。
Objective To investigate the anti-prepregnancy mechanism of mifepristone.Methods 86 early pregnancy patients with miscarriage requirements who were admitted to our hospital from August 2018 to August 2019 were selected as the research subjects.According to the blind drawing method,they were divided into observation group and control group,with 43 cases in each group.The control group was treated with mifepristone and misoprostol.On this basis,the observation group was treated with anordrin.The abortion situation,the time of bleeding after abortion,the time of menstrual recovery,the time of pregnancy sac discharge and the incidence of adverse reactions were compared between the two groups.Results The success rate of pregnancy termination in the observation group was 97.67%,slightly higher than the 93.02%in the control group,but the difference was not statistically significant.There was no significant difference in menstrual recovery and gestational sac discharge between the two groups;the bleeding time after abortion in the observation group was significantly shorter than that in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion The anti-pregnant effect of mifepristone is better,but the bleeding time after abortion is longer.
作者
邓纹
DENG Wen(Department of Gynecology,Xiaogan Maternal and Child Health Hospital,Xiaogan,Hubei,432000,China)
出处
《当代医学》
2021年第18期65-67,共3页
Contemporary Medicine
关键词
抗早孕
米非司酮
米索前列醇
双炔失碳酯
药物流产
Anti-early pregnancy
Mifepristone
Misoprostol
Diacetylene carbamide
Drug abortion
