摘要
目的观察清热化瘀方联合孕三烯酮胶囊治疗子宫内膜异位症的效果及对雌激素、神经生长因子(NGF)和炎性因子的影响。方法选取2018年7月—2019年12月我院收治的子宫内膜异位症112例为研究对象,根据治疗方法不同分为观察组和对照组,每组56例。对照组给予孕三烯酮胶囊,观察组在对照组基础上加用清热化瘀方,3个月为1个疗程。治疗2个疗程后观察并比较2组临床疗效、痛经程度、病变部位子宫内膜厚度,生殖激素[孕激素(P)、雌二醇(E_(2))、卵泡刺激素(FSH)、黄体生成素(LH)],NGF、炎性因子[白细胞介素(IL)-1β、IL-8和肿瘤坏死因子-α(TNF-α)]水平及不良反应。结果观察组总有效率高于对照组(P<0.05)。2组治疗后痛经程度、病变部位子宫内膜厚度、E_(2)、FSH、P、LH、NGF、IL-1β、IL-8和TNF-α较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05,P<0.01)。2组不良反应比较差异无统计学意义(P>0.05)。结论清热化瘀方联合孕三烯酮胶囊治疗子宫内膜异位症效果显著,可有效降低痛经程度及雌激素水平,并降低机体NGF和炎性因子,且不增加不良反应。
Objective To observe clinical efficacy of Qingre Huayu Recipe combined with Gestrinone Capsule in treatment of patients with endometriosis and its effects on estrogen,nerve growth factor(NGF)and inflammatory factors.Methods A total of 112 patients with endometriosis admitted during July 2018 and December 2019 were selected,and the patients were divided into observation group(n=56)and control group(n=56)according to different treatment methods.Control group was treated with Gestrinone Capsule,while observation group was supplemented with Qingre Huayu recipe on the basis of treatment for control group.All the patients were treated for 3 months as one course of treatment.After two courses of treatment,curative efficacy,dysmenorrhea score,endometrial thickness at the lesion site,reproductive hormones[progesterone(P),estradiol(E_(2)),follicle stimulating hormone(FSH),luteinizing hormone(LH)],NGF,inflammatory factors[interleukin(IL)-1β,IL-8,tumor necrosis factor-α(TNF-α)]levels and incidence rate of adverse reactions were observed and compared in two groups.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05).After treatment,values of dysmenorrhea score,endometrial thickness at the lesion site,E_(2),FSH,P,LH,NGF,IL-1β,IL-8 and TNF-αlevels were significantly lower than those before treatment in two groups,and values of the above indexes in observation group were significantly lower than those in control group(P<0.05,P<0.01).There was no significant difference in incidence rate of adverse reactions between two groups(P>0.05).Conclusion Qingre Huayu Recipe combined with Gestrinone Capsule in treatment of patients with endometriosis may achieve significantly clinical efficacy,effectively reduce dysmenorrhea degree and estrogen level and decrease levels of body NGF and inflammatory factors without increasing incidence rate of adverse reactions.
作者
贾聚坤
刘桂英
魏倩璞
张英
张莹
JIA Ju-kun;LIU Gui-ying;WEI Qian-pu;ZHANG Ying;ZHANG Ying(Department of Pharmacy,the People's Hospital of Shijiazhuang,Shijiazhuang 050011,China;Maternal and Child Health Care Hospital of Bazhou,Bazhou,Hebei 065700,China)
出处
《解放军医药杂志》
CAS
2021年第6期101-104,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
河北省中医药管理局科研计划项目(2018253)。
