摘要
目的:探讨血清甲胎蛋白异质体(AFP-L3)、角蛋白19片段(CYFRA21-1)及可溶性B7-H3(sB7-H3)对原发性肝癌(PHC)患者近期疗效及预后的预测价值。方法:选取2016年1月至2017年1月就诊的PHC患者、肝良性肿瘤患者及健康体检者,分别设为PHC组(n=70)、肝良性肿瘤组(n=40)及正常对照组(n=40)。采用酶联免疫吸附法测定3组受试者的血清AFP-L3、CYFRA21-1及sB7-H3水平,分析其与PHC患者近期疗效及预后的关系,及三者对PHC的诊断效能。结果:与正常对照组比较,PHC组和肝良性肿瘤组血清AFP-L3、CYFRA21-1及sB7-H3水平均显著上升(P<0.05);与肝良性肿瘤组比较,PHC组血清AFP-L3、CYFRA21-1及sB7-H3水平均显著上升(P<0.05)。治疗后完全缓解(CR)+部分缓解(PR)组和稳定(SD)+进展(PD)组患者血清AFP-3、CYFRA21-1及sB7-H3水平均较治疗前降低(P<0.05),且CR+PR组均显著低于SD+PD组(P<0.05)。生存期>3年组患者血清AFP-3、CYFRA21-1及sB7-H3水平均显著低于生存期<3年组(P<0.05)。血清AFP-3、CYFRA21-1、sB7-H3联合检测诊断PHC的敏感度高于单独检测,三者联合检测诊断PHC的ROC曲线下面积均大于单一检测。结论:血清AFP-L3、CYFRA21-1及sB7-H3与PHC患者的近期疗效及远期预后均具有一定相关性,联合AFP-L3、CYFRA21-1及sB7-H3水平检测诊断PHC时诊断效能更高,具有一定的临床价值。
Objective:To investigate the relationship of serum alpha-fetoprotein heterosomes(AFP-L3),keratin 19 fragments(CYFRA21-1)and soluble B7-H3(sB7-H3)on the short-term efficacy and prognosis of patients with primary liver cancer.Methods:PHC patients,benign liver tumor patients and health check-ups were selected from January 2016 to January 2017.They were divided into primary liver cancer group(n=70),liver benign tumor group(n=40)and normal control group(40).Serum AFP-3,CYFRA21-1 and sB7-H3 levels were determined by enzyme-linked immunosorbent assay in three groups.The relationship between serum AFP-3,CYFRA21-1 and sB7-H3 level on the short-term curative effect and prognosis of PHC patients,the diagnostic efficacy of three index to PHC were analyzed.Results:The serum AFP-L3,CYFRA21-1 and sB7-H3 levels in three groups were statistically different(P<0.05).Compared with the normal control group,The serum AFP-L3,CYFRA21-1 and sB7-H3 levels in primary liver cancer group and benign liver tumor group increased significantly(P<0.05).Compared with benign liver tumors,serum AFP-L3,CYFRA21-1 and sB7-H3 levels in primary liver cancer group increased significantly(P<0.05).The serum AFP-3,CYFRA21-1 and sB7-H3 levels were lower in CR+PR group and SD+PD group after treatment(P<0.05).The level of serum AFP-3,CYFRA21-1 and sB7-H3 in CR+PR group were significantly lower than those in SD+PD group(P<0.05).The level of serum AFP-3,CYFRA21-1 and sB7-H3 were significantly lower in OS>3 years group than in OS>3 years group(P<0.05).The sensitivity of serum AFP-3,CYFRA21-1,sB7-H3 combined detection diagnostic PHC was higher than that of individual detection.The product under the ROC curve of the diagnostic PHC was larger than that of single detection.Conclusion:Serum AFP-L3,CYFRA21-1 and sB7-H3 have a certain correlation with the short-term curative effect and long-term prognosis of PHC patients.Combined with the detection of AFP-L3,CYFRA21-1 and sB7-H3 levels in the diagnosis of PHC,the diagnostic efficiency is higher and has certain clinical value.
作者
刘炼玲
李勇
LIU Lian-ling;LI Yong(Department of Gastroenterology,Wanzhou District People's Hospital,Chongqing,404100,China)
出处
《中西医结合肝病杂志》
CAS
2021年第6期502-505,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
重庆市自然科学基金面上项目(No.cstc2017jcyj-mxmX0368)。
