摘要
目的探讨不同类型运动干预降低非酒精性脂肪性肝病(NAFLD)患者肝内脂质含量的靶向作用和量效关系。方法在Web of Science、PubMed、中国知网、万方及维普网等数据库检索文献,依据纳入与排除标准最终筛选出21篇文献进行分析,比较有氧运动、抗阻运动、高强度间歇运动及组合运动干预NAFLD患者的方案及效果差异。结果有氧运动主要通过分解消耗脂肪降低肝内脂质含量,抗阻运动主要通过促进骨骼肌吸收游离脂肪酸减少肝内脂质堆积。虽然目前有氧运动联合抗阻运动的效果与单纯有氧运动或抗阻运动的短期效果在统计学上难以区分,但从长期效果看,结合抗阻运动能保持骨骼肌对游离脂肪酸的利用率,高强度间歇运动可有效改善肝硬化和恢复Kupffer细胞功能。结论有氧运动、抗阻运动和高强度间歇运动单独干预或组合干预均可降低NAFLD患者的肝内脂质含量,但剂量选择和靶向作用不同,高强度间歇运动相对更高效、省时,推荐NAFLD患者采取组合干预形式。
Objective To analyze the targeting effect of different exercises on intrahepatic lipid(IHL)content of patients with non-alcoholic fatty liver disease(NAFLD)and the exercise dose levels.Methods By searching literature in the databases such as Web of Science(WoS),PubMed and CNKI etc.,21 articles were filtered and analyzed according to inclusion&exclusion criteria eventually.The program and effect of aerobic exercise(AE),resistance exercise(RE)and high-intensity interval training(HIIT)and combination of exercise intervention were compared in NAFLD patients.Results AE reduced IHL content by consuming adipose tissue;RE reduced the accumulation of IHL by promoting the absorption of non-esterified fatty acid(NEFA)in skeletal muscles mainly with the effective increase of muscle mass and strength.Although the short-term effect of AE+RE was statistically indistinguishable from AT or RE alone,combination of RE could maintain the utilization rate of NEFA by skeletal muscle and promote the formation of a virtuous cycle of systemic metabolism as a long-term benefit.Conclusions Different types of exercise can reduce intrahepatic lipid(IHL)content of patients with NAFLD,but the dose and targeted role are different.HIIT is more efficient and time-saving.The combination of the both is still recommended for NAFLD patients when time and space conditions are available.
作者
赵璨
王人卫
高炳宏
ZHAO Can;WANG Renwei;GAO Binghong(School of Physical Education and Training,Shanghai University of Sport,Shanghai 200438,China;School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China)
出处
《上海体育学院学报》
CSSCI
北大核心
2021年第6期80-92,共13页
Journal of Shanghai University of Sport
基金
国家自然科学基金项目(31771316)
上海市人类运动能力开发与保障重点实验室(上海体育学院)资助项目(11DZ2261100)。
关键词
运动训练
非酒精性脂肪性肝病
有氧运动
抗阻运动
高强度间歇运动
组合运动干预
肝内脂质含量
exercise
non-alcoholic fatty liver
aerobic exercise
resistance exercise
high-intensity interval training
combined exercise intervention
intrahepatic lipid
