摘要
目的通过观察胃结直肠癌患者术后体重指数(body mass index,BMI)与预后的关系,探讨胃结直肠癌患者预后与体重指数的关系,为胃结直肠癌患者术后及保健如何控制体重提供参考。方法回顾性分析2014年1月至2017年12月在唐山市妇幼保健院和唐山市工人医院外科胃结直肠癌543例。通过对患者BMI进行分组,比较各组预后差异。结果在单因素分析中显示:胃结直肠癌患者术后BMI≤18.5 kg/m^(2)和18.5 kg/m^(2)<BMI<23.9 kg/m^(2)的5年OS差异有统计学意义(=53.639,P<0.05);BMI>27 kg/m^(2)与23.9 kg/m^(2)<BMI<26.9 kg/m^(2)差异有统计学意义(=6.079,P=0.014),即体重过低或肥胖患者5年OS明显下降(P<0.05)。多因素分析中:体重过低BMI≤18.5 kg/m^(2)(RR=3.395,95%CI:1.701~6.778,P=0.001)可作为5年OS相关的独立危险因素,而体重正常(18.5 kg/m^(2)<BMI<23.9 kg/m^(2))(RR=0.444,95%CI:0.223~0.884,P=0.021)和超重(24 kg/m^(2)≤BMI<26.9 kg/m^(2))(RR=0.386,95%CI:0.166~0.898,P=0.027)可作为5年OS相关的独立保护因素,且超重相对于体重正常胃结直肠癌患者更具有保护作用。结论术后体重过低及肥胖可作为影响胃结直肠癌生存率的独立影响因素,处于该体重指数的患者应该控制体重在正常体重范围。
Objective To investigate the correlation between body mass index(BMI)the prognosis of patients with gastric and colorectal cancer after operation.Methods The clinical data about 543 patients with gastric and colorectal cancer who were treated in Tangshan Hospital for Maternal and Child Health and Tangshan Workers’Hospital from January 2012 to December 2018 were retrospectively analyzed.And the patients were divided into groups according BMI to evaluate the prognosis of different groups.Results The single factor analysis showed that there was significant difference in 5-year OS between BMI≤18.5kg/m^(2) group and BMI in 18.5~23.9kg/m^(2) group(P<0.05),so was between BMI>27kg/m^(2) group and BMI 23.9~26.9kg/m^(2) group(P<0.05).The multiple factor analysis showed that low weight(BMI≤18.5kg/m^(2))could be regarded as 5-year OS independent risk factors,however,the normal weight(BMI 18.5~23.9kg/m^(2))and overweight(BMI 24~26.9kg/m^(2))could be regarded as 5-year OS independent protective factor,especially in overweight patients.Conclusions The postoperative underweight and obesity can be regarded as an independent factor affecting the survival rate of patients with gastric and colorectal cancer,and the patients should control their body weight in the range of normal weight.
作者
杨学娜
王金英
母俊婷
肖倩
裴晓娇
廉丹丹
YANG Xuena;WANG Jinying;MU Junting(Tangshan Workers Hospital,Hebei,Tangshan 063000,China;不详)
出处
《河北医药》
CAS
2021年第11期1668-1671,共4页
Hebei Medical Journal
基金
河北省中医药管理局中医药课题计划(编号:2021411)。
关键词
胃结直肠癌
体重指数
超重
体重过低
预后
gastric and colorectal cancer
body mass index
overweight
underweight
prognosis
