摘要
目的探究桥本甲状腺炎患者外周血CD4+T淋巴细胞和25羟维生素D[25(OH)D]水平的表达及其相关性。方法抽取2018年10月至2019年10月新乡市第一人民医院收治的88例桥本甲状腺炎患者为患病组,患病组患者又按照其甲状腺功能状态分为甲状腺功能正常组(26例)、亚临床甲状腺功能减低组(24例)和临床甲状腺功能减低组(38例)。另抽取同期在医院体检的健康者60例为健康组。比较患病组和健康组、不同甲状腺功能状态桥本甲状腺炎患者、治疗前后桥本甲状腺炎患者外周血辅助性T细胞17(Th17)/CD4+T细胞百分率以及25(OH)D水平,用Spearman检验和Pearson检验分析桥本甲状腺炎患者外周血Th17/CD4+T细胞百分率和25(OH)D水平之间的相关性。结果患病组Th17/CD4+T细胞百分率为(3.98±0.89)%,高于健康组的(2.28±0.25)%,P<0.05;患病组25(OH)D水平为(13.37±3.49)ng/ml,低于健康组的(17.58±5.63)ng/ml(P<0.05);Th17/CD4+T细胞百分率随甲状腺功能的减低而升高(P<0.05),25(OH)D水平随甲状腺功能的减低而下降(P<0.05)。治疗后,桥本甲状腺炎患者Th17/CD4+T细胞百分率为(2.35±0.36)%,低于治疗前的(3.98±0.89)%,P<0.05;25(OH)D水平为(16.94±5.37)ng/ml,高于治疗前的(13.37±3.49)ng/ml(P<0.05)。Spearman相关性检验显示,外周血Th17/CD4+T细胞百分率与桥本甲状腺炎呈正相关(P<0.05),25(OH)D水平与桥本甲状腺炎呈负相关(P<0.05)。Pearson相关性检验显示,桥本甲状腺炎患者外周血Th17/CD4+T细胞百分率与25(OH)D水平呈负相关(P<0.05)。结论桥本甲状腺炎患者外周血中Th17/CD4+T细胞百分率呈上升趋势,25(OH)D水平呈下降趋势,两项指标水平与桥本甲状腺炎发生、病情发展及疾病转归关系密切,有助于指导桥本甲状腺炎的临床管理。
Objective To investigate the expression and correlation of cluster differentiation(CD)4+T lymphocytes and 25-hydroxyvitamin D[25(OH)D]in peripheral blood in patients with Hashimoto’s thyroiditis.Methods A total of 88 patients with Hashimoto’s thyroiditis and 60 healthy individuals in the First People’s Hospital of Xinxiang from October 2018 to October 2019 were selected,and set as disease group and control group,respectively.According to their thyroid function,the patients in the disease group were divided into normal thyroid function group(26 cases),subclinical hypothyroidism group(24 cases),and clinical hypothyroidism group(38 cases).The peripheral blood T helper cell 17(Th17)/CD4+T cell percentage,and 25(OH)D level were compared between disease group and control group,among patients with different thyroid function status;and these indexes of patients with Hashimoto’s thyroiditis before and after treatment were compared.Spearman test and Pearson test were used to analyze the correlation between Th17/CD4+T cell percentage and 25(OH)D level in peripheral blood of patients with Hashimoto’s thyroiditis.Results Th17/CD4+T cell percentage of disease group was(3.98±0.89)%,higher than the(2.28±0.25)%of healthy group(P<0.05);25(OH)D level of disease group was(13.37±3.49)ng/ml,lower than the(17.58±5.63)ng/ml of healthy group(P<0.05).With the decrease of thyroid function,the percentage of Th17/CD4+T cells gradually increased(P<0.05),and the level of 25(OH)D gradually decreased(P<0.05).After treatment,the percentage of Th17/CD4+T cells in Hashimoto’s thyroiditis patients was(2.35±0.36)%,lower than the(3.98±0.89)%before treatment(P<0.05);the level of 25(OH)D in Hashimoto’s thyroiditis patients was(16.94±5.37)ng/ml after treatment,higher than the(13.37±3.49)ng/ml before treatment(P<0.05).Spearman correlation analysis showed that the percentage of Th17/CD4+T cells in peripheral blood was positively correlated with Hashimoto’s thyroiditis(P<0.05);and 25(OH)D level was negatively correlated with Hashimoto’s thyroiditis(P<0.05).Pearson correlation test showed that the percentage of Th17/CD4+T cells in peripheral blood of Hashimoto’s thyroiditis patients was negatively correlated with 25(OH)D level(P<0.05).Conclusions Patients with Hashimoto’s thyroiditis have increased Th17/CD4+T cell percentage and a decreased 25(OH)D level.Moreover,these indicators are closely related to the occurrence,development,and outcome of Hashimoto’s thyroiditis,which can be used to guide the clinical management of the disease.
作者
杨艳
邱伟
邹慧
Yang Yan;Qiu Wei;Zou Hui(Department of Endocrinology,the First People’s Hospital of Xinxiang,Xinxiang 453000,China)
出处
《中国实用医刊》
2021年第9期63-66,共4页
Chinese Journal of Practical Medicine
