摘要
目的:研究虫草补肾胶囊对糖尿病性骨质疏松患者骨转化标志物的影响。方法:选择2016年12月~2019年11月本院收治的107例糖尿病性骨质疏松患者作为研究对象,随机分为对照组(n=54)和观察组(n=53)。对照组给予碳酸钙治疗,观察组接受虫草补肾胶囊治疗,对比两组治疗效果、中医证候积分、骨转化标志物[骨钙素、1型前胶原氨基端前肽(tP1NP)、甲状旁腺素(PTH)、25‑羟基维生素D、β‑异构化的c端肽(β‑CTx)]的变化情况,同时记录患者不良反应的发生情况。结果:治疗后,观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组中医证候积分中腰膝酸软、腰背疼痛、下肢萎弱、倦怠乏力、步履艰辛及目眩头晕的评分较对照组低,差异有统计学意义(P<0.05);观察组的骨钙素、PTH、tP1NP、β‑CTx水平低于对照组,差异有统计学意义(P<0.05);25‑羟基维生素D水平高于对照组,差异有统计学意义(P<0.05);观察组骨密度均高于对照组,差异有统计学意义(P<0.05)。结论:糖尿病性骨质疏松患者经虫草补肾胶囊治疗,可改善临床症状,提高骨密度,改善骨转化标志物指标水平,疗效确切。
Objective:To study the effect of Chongcao Bushen Capsules on bone turnover markers in patients with diabetic osteoporosis.Methods:A total of 107 patients with diabetic osteoporosis treated in our hospital from December 2016 to November 2019 were enrolled.They were divided into the control group(n=54)and the observation group(n=53)by random number ta-ble.The control group was treated with calcium carbonate,and the observation group was treated with Chongcao Bushen Cap-sules.The treatment effects,TCM syndrome scores,and bone turnover markers[including osteocalcin,type 1 procollagen ami-no-terminal propeptide(tP1NP),parathyroid hormone(PTH),25-hydroxyvitamin D,andβ-isomerized c-terminal peptide(β-CTx)],and the incidence of adverse reactions in the two groups were observed and compared.Results:After treatment,the total effective rate of treatment in the observation group(94.44%)was higher than that in the control group(73.58%),and the difference was statistically significant(P<0.05).The scores of symptoms including waist and knee weakness,back and waist pain,lower limb weakness,fatigue and tiredness,difficult walking and dizziness in the observation group were shown to be lower than the control group,and the difference was statistically significant(P<0.05).The levels of osteocalcin,PTH,tP1NP,andβ-CTx in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The 25-hydroxyvitamin D in the observation group was higher than the control group,and the difference was statistically significant(P<0.05).Bone density in both male and female in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:For patients with diabetic osteoporosis,Chongcao Bushen Capsule can help improve their clinical symptoms,bone density and the level of bone turnover markers.
作者
段俊红
梁贵廷
DUAN Jun-hong;LIANG Gui-ting(The Chinese Medicine Hospital of Shijiazhuang City,Shijiazhuang 050000,China)
出处
《海南医学院学报》
CAS
2021年第12期898-901,909,共5页
Journal of Hainan Medical University
基金
河北省中医药管理局中医药类科研计划课题(2016092)。
