摘要
目的研究中性粒细胞(NE)、血小板计数(PLT)与免疫球蛋白(Ig)在鉴别诊断慢性乙型肝炎(chronic hepatitis B,CHB)和乙肝肝硬化(hepatitis B cirrhosis,HBC)中的价值及其临床意义。方法选取2017年6月~2020年6月收治的慢性乙型肝炎患者150例(以下简称CHB组);乙肝肝硬化患者150例(以下简称HBC组)。另外选取同期诊治的100例乙肝表面抗原(HBsAg)为阴性的健康患者作为对照组。所有患者空腹采集外周静脉血3 ml,离心(3000 r/min,15 min),取血清作为检测样本。检测CHB组、HBC组和对照组患者外周血清中NE、PLT和免疫球蛋白(包括IgA,IgM,IgG)的水平。结果①CHB组和HBC组的NE水平差异无统计学意义(P>0.05);但是CHB组和HBC组的NE水平均明显低于对照组,差异有统计学意义(P<0.05);CHB组和对照组的PLT水平明显高于HBC组,差异有统计学意义(P<0.05);②CHB组IgA和IgG的含量水平与HBC组差异明显(P<0.05),但是IgM的差异无统计学意义(P>0.05)。CHB组和HBC组中IgA、IgM、IgG的水平,明显高于对照组,差异有统计学意义(P<0.05)。③代偿期组和失代偿期组的NE的水平差异无统计学意义(P>0.05),PLT差异有统计学意义(P<0.05)。④代偿期组中IgA的水平明显低于失代偿期,差异有统计学意义(P<0.05),但是IgM、IgG水平两组差异无统计学意义(P>0.05)。结论中性粒细胞、血小板计数与免疫球蛋白指标检测在诊断慢性乙型肝炎和乙肝肝硬化中具有一定的临床指导意义。
Objective To study the value and clinical significance of neutrophil(NE),platelet count(PLT)and immunoglobulin(Ig)in the differential diagnosis of chronic hepatitis B(CHB)and hepatitis B cirrhosis(HBC).Methods 150 patients with chronic hepatitis B(CHB group)were selected from June 2017 to June 2020 in our hospital;150 patients with hepatitis B cirrhosis(HBC group).In addition,100 healthy patients with negative HBsAg were selected as control group.3 ml peripheral venous blood was collected from all patients on an empty stomach and centrifuged(3000 r/min,15 min),and serum was taken as test sample.The levels of NE,PLT and immunoglobulin(including IgA,IgM,IgG)in peripheral serum of CHB group,HBC group and control group were detected.Results①There was no significant difference in NE level between CHB group and HBC group(P>0.05);however,NE level in CHB group and HBC group was significantly lower than that in control group(P<0.05);PLT level in CHB group and control group was significantly higher than that in HBC group,with significant difference(P<0.05);②the content of IgA and IgG in CHB group was significantly different from that in HBC group(P<0.05),but there was no significant difference in IgM(P>0.05).The levels of IgA,IgM and IgG in CHB group and HBC group were significantly higher than those in control group(P<0.05).③There was no significant difference in NE level between compensated group and decompensated group(P>0.05),but PLT was significantly different(P<0.05).④The level of IgA in the compensatory group was significantly lower than that in the decompensated stage(P<0.05),but there was no significant difference in the levels of IgM and IgG between the two groups(P>0.05).Conclusion The detection of neutrophil,platelet count and immunoglobulin has certain clinical significance in the diagnosis of chronic hepatitis B and hepatitis B cirrhosis.
作者
林洁莲
LIN Jie-lian(People's Hospital of Chenghai District,Shantou 515800,China)
出处
《中国处方药》
2021年第6期150-152,共3页
Journal of China Prescription Drug
