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Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2 被引量:2

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摘要 Dear Editor,Middle East respiratory syndrome-related coronavirus(MERS-CoV)is the pathogen responsible for the outbreak of MERS,and we are currently being affected by coronavirus disease 2019(COVID-19)due to infection by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The S protein of SARS-CoV-2 or MERS-CoV binds angiotensin-converting enzyme 2(ACE2)or dipeptidyl peptidase-4(DPP4),respectively,to facilitate viral particles entry into cells1.The COVID-19 pandemic has caused major socioeconomic disruptions globally.
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2021年第5期1433-1435,共3页 信号转导与靶向治疗(英文)
基金 This work was supported by Hong Kong Research Grant Council(RGC)grants(11101717 and 11103620),NSFC(21778045 and 32070702) Shenzhen government research grant(JSGG20200225150702770).
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