摘要
目的:探究清胰汤联合生长抑素、肠内营养治疗对重症急性胰腺炎患者肠道功能和炎性因子的影响。方法:前瞻性分析,选取2017年10月-2019年10月本院收治的80例重症急性胰腺炎患者为研究对象,将80例患者进行编号,按照随机数字表法,将单号患者纳入对照组,双号患者纳入观察组。对照组给予生长抑素及肠内营养治疗,观察组给予清胰汤联合生长抑素、肠内营养治疗。比较两组患者的肠道功能、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)、血清淀粉酶(AMS)、血清二胺氧化酶(DAO)、D-乳酸水平及并发症发生情况。结果:观察组的治疗总有效率高于对照组(P<0.05);观察组的腹痛缓解时间、腹胀缓解时间、肠鸣音恢复时间、排便恢复时间、排气时间均早于对照组(P<0.05);治疗前两组患者血清AMS、DAO及D-乳酸水平比较差异无统计学意义(P>0.05),治疗后观察组患者血清AMS、DAO及D-乳酸水平低于对照组(P<0.05);治疗前两组患者CRP、TNF-α及IL-6水平比较差异无统计学意义(P>0.05),治疗后观察组CRP、TNF-α及IL-6水平均低于对照组(P<0.05);观察组的并发症发生率低于对照组(P<0.05)。结论:清胰汤联合生长抑素、肠内营养治疗对重症急性胰腺炎患者的治疗效果显著,安全性较高,值得应用于临床治疗中。
Objective:To explore the effects of Qingyi Decoction combined with Somatostatin and enteral nutrition on intestinal function and inflammatory factors in patients with severe acute pancreatitis.Method:Prospective analysis was carried out,according to the random number table method,80 patients with severe acute pancreatitis in our hospital from October 2017 to October 2019 were divided into control group and observation group according to the random number table,with 40 cases in each group.The control group was given Somatostatin and enteral nutrition,while the observation group was given Qingyi Decoction combined with Somatostatin and enteral nutrition.Intestinal function,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6),serum amylase(AMS),serum diamine oxidase(DAO),D-lactic acid level and complications were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group(P<0.05);the abdominal pain relief time,abdominal distension relief time,bowel sounds recovery time,defecation recovery time and exhaust time of the observation group were less than those of the control group(P<0.05);there was no significant difference in the levels of AMS,DAO and D-lactic acid between the two groups before treatment(P>0.05),and after treatment,the levels of AMS,DAO and D-lactic acid in the observation group were lower than those in the control group(P<0.05);before treatment,there was no significant difference in CRP,TNF-αand IL-6 levels between the two groups(P>0.05),and after treatment,the levels of CRP,TNF-αand IL-6 in the two groups decreased,and those in the observation group were lower than those in the control group(P<0.05);the incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion:Qingyi Decoction combined with Somatostatin and enteral nutrition has significant therapeutic effect on patients with severe acute pancreatitis,it is safe and worthy of clinical application.
作者
郑长春
陈建辉
ZHENG Changchun;CHEN Jianhui(People’s Hospital of Xingshan County,Xingshan 443700,China;不详)
出处
《中外医学研究》
2021年第15期123-126,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
清胰汤
生长抑素
肠内营养
重症急性胰腺炎
Qingyi Decoction
Somatostatin
Enteral nutrition
Severe acute pancreatitis
