摘要
目的:回顾性探讨hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962对非小细胞肺癌联合诊断的价值。方法:纳入2016年1月~2018年12月我院收治的早期非小细胞肺癌120例为肿瘤组、肺部良性疾病患者120例为良性病组和健康体检者120例为对照组。实时荧光定量PCR检测3组人员血清中hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962的相对表达量;用受试者工作特征曲线(receiver operating characteristic curve,ROC)的AUC分析hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962检测在早期非小细胞肺癌中的诊断意义。结果:早期非小细胞肺癌患者血清中hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962的相对表达量均高于良性病患者和健康体检者。血清中hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962在肿瘤组与良性组的灵敏度分别为83%、94%、85%,特异度分别为91%、63%、79%。血清中hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962在肿瘤组与对照组的灵敏度分别为93%、87%、88%,特异度分别为93%、88%、83%。血清中hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962联合对非小细胞肺癌诊断的灵敏度为91.67%,特异度为87.91%,准确度为89.17%。结论:血清中hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962的相对表达量检测可作为非小细胞肺癌的潜在标志。
Objective To retrospectively explore the value of hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962 in the joint diagnosis of non-small cell lung cancer.Methods 120 patients with early non-small cell lung cancer admitted to our hospital from January 2016 to December 2018 were included in the tumor group,120 patients with benign lung diseases were included in the benign lung disease group,and 120 healthy subjects were included in the control group.The relative expressions of hsa_circ_0109320,hsa_circ_0134501 and hsa_circ_0005962 in serum of the three groups were detected by real-time fluorescence quantitative PCR.The AUC of receiver operating characteristic curve(ROC)was used to analyze the diagnostic significance of hsa_circ_0109320,hsa_circ_0134501 and hsa_circ_0005962 detection in early NSCLC.Results The serum levels of hsa_circ_0109320,hsa_circ_0134501 and hsa_circ_0005962 in patients with early NSCLC were higher than those in patients with benign disease and healthy subjects.The sensitivity,specificity and specificity of serum hsa_circ_0109320,hsa_circ_0134501,hsa_circ_0005962 were 83%,94%,85%,91%,63%and 79%,respectively,in the tumor group and the benign group.The sensitivity,specificity and specificity of serum hsa_circ_0109320,hsa_circ_0134501 and hsa_circ_0005962 were 93%,87%and 88%,respectively,in the tumor group and the control group.The sensitivity,specificity and accuracy of hsa_circ_0109320,hsa_circ_0134501 and hsa_circ_0005962 in serum for the diagnosis of NSCLC were 91.67%,87.91%and 89.17%respectively.Conclusion The relative expression of hsa_circ_0109320,hsa_circ_0134501 and hsa_circ_0005962 in serum can be used as a potential marker of NSCLC.
作者
韩慧芳
任丽坤
Han Hui-fang;Ren Li-kun(Department of Oncology,Second Hospital,Handan City,Handan 056500,China)
出处
《湖南师范大学学报（医学版）》
2021年第3期199-203,共5页
Journal of Hunan Normal University(Medical Sciences)
