摘要
目的研究垂体后叶素在抢救支气管扩张(BE)合并咯血患者中的疗效。方法选取2017年1月-2020年1月东方市人民医院收治的BE合并咯血患者92例为研究对象,采用随机数字表法将92例患者分为联合组32例、垂体后叶素组30例、硝酸甘油组30例,垂体后叶素组给予垂体后叶素治疗,硝酸甘油组给予硝酸甘油治疗,联合组在常规治疗基础上,同时给予垂体后叶素和硝酸甘油治疗。比较三组临床疗效,用药后止血时间和咯血总量,半年内咯血复发率及治疗期间出现的不良反应发生率。结果联合组总有效率(90.63%)明显高于垂体后叶素组(73.33%)、硝酸甘油组(66.67%)(P<0.05);垂体后叶素组咯血时间、咯血总量明显小于硝酸甘油组,联合组咯血时间、咯血总量明显小于垂体后叶素组(P<0.05);联合组0-1个月咯血复发率与硝酸甘油组比较有显著差异(P<0.05),其他时间段咯血复发率组间比较无显著差异(P>0.05);垂体后叶素组总不良反应发生率(40.00%)明显高于硝酸甘油组(13.33%),联合组总不良反应发生率(3.13%)明显低于垂体后叶素组(P<0.05)。结论垂体后叶素用于BE合并咯血患者的抢救中,持效确切,但容易引不良反应,与硝酸甘油联合应用能进一步提高治疗效果,同时可减少不良反应发生率.
Objective To investigate the clinical effects of pituitrin in treatment of bronchiectasis with hemoptysis.Methods 92 patients with bronchiectasis with hemoptysis were randomLy divided into 3 groups:nitroglycerin(NTG)group(n=30)given NTG by intravenous infusion,pituitrin(PIT)group(n=30)given PIT by intravenous infusion,and combined group(n=32)given both drugs.The effects were observed for 6 months.Results The total effec tive rate of the combined group was 90.53%,significantly higher than those of the PIT group(73.33%)and NTG group(66.67%)(both P<0.05).The hemoptysis time of the PIT group was(9.18±2.19)d,significantly shorter than that of the NTG group[(11.90±1.34)d,P<0.05)].The hemoptysis time of the combined group was(5.67±1.23)d,significanlly shorter than that of the PIT group(P<0.05).The hemoptysis amount of the PIT group was(792.97±97.86)mL,significantly less than that of the NTG group[(792.97±97.86)mL,P<0.05].The hemoptysis amount of the combined group was(581.46±40.52)mL,significantly shorter than that of the PIT group(P<0.05).The recurrence rate during the 0〜1 month of the combined group was 0,significantly lower than the other 2 groups(both P<0.05).There were no significant differences in the recurrence rate after the period 0〜1 month.The total incidence rate of the PIT group was 40.00%,significantly high-er than that of the NTG group(13.33%,P<0.05).The total incidence rate of the combined group was 3.13%,significantly lower than that of the PIT group(13.33%,P<0.05).Conclusion PIT is effective in the treatment of bronchiectasis with hemoptysis,however,it is easy to cause side effects.PIT combined with NTG helps raise the curative effects and reduce the side effects.
作者
吉雪芳
赵仕玉
文小兰
JI Xuefang;ZHAO Shiyu;WEN Xiaolan(Department of Respiratory Medicine,Dongfang People’s Hospital,Dongfang Hainan 512600,China)
出处
《中国急救复苏与灾害医学杂志》
2021年第6期647-649,660,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
海南省医药卫生科研项目(编号:19A200093)。
