摘要
目的探讨多西环素和头孢曲松联合甲硝唑治疗盆腔炎的临床疗效。方法选取长沙市第三医院2018年3月—2019年3月收治的盆腔炎患者80例,遵循随机分组原则分为对照组和观察组,每组40例。对照组予以头孢曲松联合多西环素治疗,观察组在对照组基础上加用甲硝唑治疗。2组均连续治疗3周。比较2组临床疗效,治疗前后炎症指标[超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC)、降钙素原(PCT)]、炎性因子[粒细胞-巨噬细胞集落刺激因子(GM-CSF)、肿瘤坏死因子α(TNF-α)和转化生长因子β1(TGF-β1)],症状(下腹坠痛、白带异常、腰骶酸痛)改善时间,并观察2组不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后观察组hs-CRP、WBC、PCT、GM-CSF、TNF-α和TGF-β1低于对照组(P<0.05)。观察组下腹坠痛、白带异常、腰骶酸痛改善时间短于对照组(P<0.05)。2组治疗期间均未发生药物性不良反应。结论多西环素和头孢曲松联合甲硝唑治疗盆腔炎确切,可有效改善患者炎性症状,缩短症状改善时间,且安全性较高。
Objective To investigate the clinical effect of doxycycline and ceftriaxone combined with metronidazole on pelvic inflammatory disease.Methods A total of 100 cases of patients with pelvic inflammatory disease were selected from March 2018 to March 2019 in the Third Hospital of Changsha,which were divided into control group and observation group according to the principle of randomized block,with 40 cases in each group.The control group was treated with ceftriaxone combined with doxycycline,the observation group was treated with metronidazole on the basis of the control group.Both groups were treated continuously for 3 weeks.Clinical effect,inflammatory indexes(hs-CRP,WBC,PCT)and inflammatory factors(GM-CSF,TNF-αand TGF-β1)before and after treatment,improvement time of symptoms(lower abdominal pain,abnormal leucorrhea,lumbosacral pain)were compared between the two groups,and the incidence of adverse reactions were observed.Results The effective rate of observation group was higher than control group(P<0.05).After treatment,the levels of hs-CRP,WBC,PCT,GMCSF,TNF-αand TGF-β1 in the observation group were lower than those in the control group(P<0.05).The improvement time of lower abdominal pain,abnormal leucorrhea and lumbosacral pain in the observation group was shorter than that in the control group(P<0.05).No adverse drug reactions occurred in the two groups during treatment.Conclusion Doxycycline and ceftriaxone combined with metronidazole have an exact clinical effect for pelvic inflammatory disease,which can effectively improve the inflammatory symptoms of patients,shorten the time to improve symptoms,and with high safety.
作者
吴樱
WU Ying(Department of Gynaecology and Obstetrics,the Third Hospital of Changsha,Changsha 410001,China)
出处
《临床合理用药杂志》
2021年第15期42-44,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
盆腔炎
多西环素
甲硝唑
头孢曲松
治疗结果
Pelvic inflammatory disease
Doxycycline
Metronidazole
Ceftriaxone
Treatment outcome
