摘要
目的分析孕期母体外周血肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平对子代出生体重的影响。方法选择2015年1月—2016年12月分娩的已加入广州出生队列研究的1519名孕妇及其所生活产单胎新生儿为研究对象,分析母体孕期外周静脉血TNF-α、IL-6不同水平与子代出生体重之间的关系。结果孕中期母血TNF-α平均浓度为(26.1±19.0)pg/mL,IL-6平均浓度为(3.8±2.8)pg/mL。线性回归分析显示,孕期母血TNF-α(β=0,95%CI:0~0)、IL-6(β=0,95%CI:-0.02~0.02)与新生儿出生体重无统计学相关。多元Logistic回归模型分析中,母体外周血TNF-α(OR=1.01,95%CI:1.00~1.01)、IL-6(OR=1.01,95%CI:0.95~1.08)与小于胎龄儿(SGA)发生风险之间无统计学关联性。结论母体外周血TNF-α、IL-6水平对子代出生体重无影响,母体炎性因子与子代其他结局的关系仍需进一步研究。
Objective To analyze the effects of TNF-αand IL-6 levels in maternal blood during pregnancy on birth weight of offspring.MethodsA total of 1519 pregnant women who had been enrolled in the Guangzhou Birth Cohort Study from January 2015 to December 2016 and their singleton newborns were selected as subjects.The relationship between different levels of TNF-αand IL-6 in the maternal peripheral venous blood during pregnancy and the birth weight of the offspring were analyzed with the linear and multivariate logistic regression models.ResultsThe average concentration of TNF-αin second trimester serum was(26.1±19.0)pg/mL,and the average concentration of IL-6 was(3.8±2.8)pg/mL.There was no significant association between neonatal birth weight and maternal blood TNF-α(β=0,95%CI:0-0)as well as IL-6(β=0,95%CI:-0.02-0.02).The effects of maternal peripheral blood TNF-α(OR=1.01,95%CI:1.00-1.01)and IL-6(OR=1.01,95%CI:0.95-1.08)on neonatal low birth weight risk were also not statistically significant.ConclusionThere was no significant effect of the levels of TNF-αand IL-6 in maternal peripheral blood on the birth weight of offspring.The relationship between maternal inflammatory factors and other outcomes of offspring still needs further study.
作者
李宇思
刘慧慧
沈松英
卢锦华
魏雪灵
田慧舒
邱琇
LI Yusi;LIU Huihui;SHEN Songying;LU Jinhua;WEI Xueling;TIAN Huishu;QIU Xiu(Division of Birth Cohort Study, Guangzhou Women and Children′s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China)
出处
《中国生育健康杂志》
2021年第4期306-310,共5页
Chinese Journal of Reproductive Health
基金
国家自然科学基金(81673181)。
