摘要
目的:考察蔓三七提取物(MSQ)对氧嗪酸钾致小鼠急性高尿酸血症治疗效果的影响。方法:通过腹腔注射氧嗪酸钾建立高尿酸血症模型,将造模成功的雄性KM小鼠随机分为正常组、模型组、别嘌醇组(10 mg/kg)和MSQ组(300 mg/kg、600 mg/kg),并灌胃治疗5 d,检测小鼠血清中尿酸含量。结果:与正常组相比,模型组尿酸值明显增加(p≤0.001),提示造模成功;别嘌醇组明显降低由氧嗪酸钾引起的高尿酸值(p≤0.05);MSQ组(300 mg/kg、600 mg/kg)对由氧嗪酸钾引起的高尿酸值无显著性影响。结论:MSQ未表现出对氧嗪酸钾致小鼠急性高尿酸模型具有抗尿酸作用。
Objective:To investigate the effect of Gynura procumbens extract(MSQ)on the treatment of acute hyperuricemia induced by potassium oxonate in mice.Methods:Hyperuricemia model was established by intraperitoneal injection of potassium oxonate.The established male KM mice were randomly divided into normal group,model group,allopurinol group(10 mg/kg)and MSQ group(300 mg/kg,600 mg/kg),and given intragastric treatment for 5 days.The serum uric acid content of the mice was determined.Results:Compared with the normal group,the uric acid value of the model group was significantly increased(p≤0.001),indicating the success of modeling.The high uric acid value caused by potassium oxonate was significantly decreased in allopurinol group(p≤0.05).MSQ group(300 mg/kg,600 mg/kg)had no significant effect on the high uric acid value caused by potassium oxonate.Conclusion:The extract of Gynura procumbens extract(MSQ)has no antiuric effect on acute hyperuric acid induced by potassium oxonate in mice.
作者
胡居吾
HU Juwu(Instiute of Applied Chemistry,Jiangxi Academy of Sciences,Jiangxi Nanchang 330029)
出处
《生物化工》
2021年第3期1-3,8,共4页
Biological Chemical Engineering
基金
江西省重点研发项目(20203BBGL73216)
江西省科学院引进博士项目(2019-YYB-13)
江西省科学院普惠制项目(2019-XTPHl-13)。
关键词
蔓三七提取物
高尿酸血症
氧嗪酸钾
动物实验
Gynura procumbens extract
hyperuricemia
potassium oxazine
animal experiments
