摘要
羽扇豆醇是一种广泛存在于多种中草药和食源性植物中的三萜类化合物,具有抗氧化、抗炎及促进皮肤愈合等多种药理学活性。近年来的研究发现羽扇豆醇对肝癌、肺癌、食管癌等多种肿瘤细胞具有抗肿瘤作用,其作用机制主要为抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭和转移等。通过总结近年来羽扇豆醇抗肿瘤作用相关研究进展,对其体内外药理活性和分子机制进行综述,以期为羽扇豆醇作为抗肿瘤潜在药物提供理论依据,并为其抗肿瘤的机制研究提供参考。
Lupeol is a kind of triterpenoid widely found in a variety of Chinese herbal medicines and food-derived plants.It has multiple pharmacological activities such as antioxidant,anti-inflammatory and promoting skin healing.Recent studies have found that lupeol has anti-tumor effects on liver cancer,lung cancer,esophageal cancer and other tumor cells.The mechanisms of action are mainly by inhibiting tumor cell proliferation,inducing tumor cell apoptosis,and suppressing tumor cell invasion and metastasis.In this review,the anti-tumor research progress,pharmacological activities and molecular mechanisms of lupeol both in vitro and in vivo are reviewed and summarized to provide a theoretical basis for lupeol as a potential anti-tumor drug,and provide references for its anti-tumor mechanism.
作者
韦燕飞
金丽杰
刘莎莎
陈婉君
成桃
刘红
刘欢
WEI Yan-fei;JIN Li-jie;LIU Sha-sha;CHEN Wan-jun;CHENG Tao;LIU Hong;LIU Huan(School of Basic Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China;The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530024, China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2021年第7期897-901,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81760757)
广西自然科学基金重点项目(No 2019JJD140032)
广西自然科学基金资助项目(No 2019JJB140107)
广西中医药大学2020年校级一般硕士研究生科研创新项目(No YCSY2020076)。
