摘要
经颅磁声电刺激是利用超声和磁场作用于大脑的新型无创神经调控技术,耦合神经元在脑电信号传递和信息交流起着关键作用。为探索该技术对耦合神经元的影响,本文利用Izhikevich神经元搭建了兴奋性-兴奋性、兴奋性-抑制性和抑制性-抑制性三种耦合模型,分别研究经颅磁声电刺激下不同刺激强度和耦合度对耦合神经元同步性的影响。结果表明随刺激强度增大,兴奋性-抑制性耦合模式下耦合神经元同步性变弱,其他两种模式在刺激强度分别为20.0μA/cm2和39.6μA/cm2时同步性由强变弱。在耦合度大于0.71时,兴奋性-兴奋性耦合模式下放电个数不再变化;在耦合度为0.71-0.96时,兴奋性-抑制性耦合模式下的放电频率增加;在耦合度大于0.96时,放电个数恒定;抑制性-抑制性耦合模式下耦合度增加放电个数增加,放电频率基本不变。研究结果有助于推动经颅磁声电刺激下神经网络的动力学研究,对神经类疾病的治疗有重要参考价值和研究意义。
Transcranial magneto-acoustic-electrical stimulation is a new non-invasive neuromodulation technology which uses ultrasound and magnetic field to act on the brain.Coupled neurons play a pivotal role in brain signal transmission and information exchange.In order to explore the effect of this technique on coupling neurons,three coupling models,namely excitation-excitability,excitation-inhibition and suppression-inhibition,were established by using Izhikevich neurons in this paper to study the effects of different stimulus intensities and coupling degrees on the synchronization of coupling neurons under transcranial magneto-acoustic and electrical stimulation.The results showed that with the increase of the stimulus intensity,the synchronization of the coupled neurons became weaker under the excitation-inhibitory coupling mode,and the synchronization of the other two modes increased from weak to strong when the stimulus intensity was 20 and 39.6,respectively.When the coupling degree is greater than 0.71,the number of lower charges in the excitation-excitability coupling mode does not change.When the coupling degree is 0.71 to 0.96,the discharge frequency increases in the excitation-inhibitory coupling mode.When the coupling degree is greater than 0.96,the number of discharge is constant.Under the inhibition-inhibitive coupling mode,the number of discharge increases with the increase of coupling degree,and the discharge frequency is basically unchanged.The results are helpful to promote the dynamic study of neural network under Transcranial magneto-acoustic-electrical stimulation and have important reference value and research significance for the treatment of neurological diseases.
作者
张帅
武健康
党君武
许家悦
李梦迪
徐桂芝
ZHANG Shuai;WU Jiankang;DANG Junwu;XU Jiayue;LI Mengdi;XU Guizhi(State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of Technology,Tianjin 300130 China;Tianjin Key Laboratory of Bioelectricity and Intelligent Health Hebei University of Technology,Tianjin 300130 China)
出处
《生命科学仪器》
2021年第2期67-75,共9页
Life Science Instruments
基金
国家自然基金(51877069)。
关键词
经颅磁声电刺激
Izhikevich神经元
电耦合
同步性指标
Transcranial magnetic-acoustic-electrical stimulation
Izhikevich neuron model
Electrical coupling
Index of neurons
