摘要
目的研究我国某农村地区饮用水六价铬暴露对血常规及氧化应激指标的影响。方法在我国西部某农村地区选取集中式供水且既往饮用水水质监测六价铬超标现象的甲、乙两乡镇,甲乡镇中选取两个行政村作为暴露组A,乙乡镇中选取两个行政村作为暴露组B;选取既往饮用水水质监测六价铬未超标的某乡镇,从中抽取两个行政村作为对照组。检测暴露组A、B和对照组出厂水和末梢水中六价铬浓度,并在3组内抽取符合纳入排除标准的调查对象,收集调查对象个人情况资料,检测静脉血血常规指标、微量元素和氧化应激酶活性。结果饮水六价铬外暴露调查显示,对照组出厂水和末梢水六价铬浓度均小于0.05 mg/L,暴露组A出厂水和末梢水六价铬浓度分别为0.066和0.065 mg/L,暴露组B出厂水和末梢水六价铬浓度分别为0.208和0.210 mg/L。本研究共纳入调查对象119人,其中对照组38人,暴露组A 42人,暴露组B 39人。三组调查对象的人口学特征相似,暴露组A的全血铁含量高于对照组(P<0.05)。暴露组B的血小板计数高于暴露组A和对照组(P<0.05)。暴露组A和暴露组B的血清超氧化物歧化酶活性均高于对照组,暴露组B的血清过氧化氢酶活性高于对照组,暴露组A的血清谷胱甘肽过氧化物酶活性高于暴露组B和对照组(P<0.05)。结论饮用水六价铬暴露未引起暴露组调查对象红细胞计数和平均红细胞体积的变化,暴露人群的部分氧化应激指标高于对照组。当地需继续做好改水工作,对既往有过饮水六价铬暴露的人群加强健康影响评价。
Objective To investigate the impact of hexavalent chromium exposure in drinking water on blood routine and oxidative stress indices among residents from a rural area in China.Methods Based on historical drinking water quality monitoring data,two villages with centralized water supply and indice was unqualified before in a rural area of western China were selected as exposure groups A and B,and two villages from the town where hexavalent chromium was qualified before were selected as control group.The levels of hexavalent chromium in finished water and terminal water of the above villages/counties was measured.Personal information was collected from the respondents,and venous blood samples were collected to measure blood routine indices,trace elements,and the activity of enzymes involved in oxidative stress.Results The levels of hexavalent chromium in finished water and terminal water were<0.05 mg/L in the control group,0.066 and 0.065 mg/L,respectively,in the exposure group A,and 0.208 and 0.210 mg/L,respectively,in the exposure group B.A total of 119 respondents were included in this study,with 38 in the control group,42 in the exposure group A,and 39 in the exposure group B.The three groups had similar demographic features;the exposure group A had significantly higher iron level in whole blood than that of the control group(P<0.05),and the exposure group B had a significantly higher platelet count than that of the exposure group A and the control group(P<0.05).The exposure groups A and B had a significantly higher activity of serum superoxide dismutase than that of the control group;the exposure group B had a significantly higher activity of serum catalase than the control group;the exposure group A had a significantly higher activity of serum glutathione peroxidase than that of the exposure group B and the control group(P<0.05).Conclusion Hexavalent chromium exposure in drinking water does not lead to obvious changes in red blood cell count and mean corpuscular volume,and some oxidative stress indices in the exposed population are higher than those in the control population.
作者
张欣怡
李毅芳
雷佩玉
李洪兴
张荣
ZHANG Xinyi;LI Yifang;LEI Peiyu;LI Hongxing;ZHANG Rong
出处
《环境卫生学杂志》
2021年第2期183-187,共5页
JOURNAL OF ENVIRONMENTAL HYGIENE
关键词
饮用水
六价铬
血常规
氧化应激
drinking water
hexavalent chromium
blood routine examination
oxidative stress
