摘要
目的分析妊娠早期甲状腺球蛋白抗体(TgAb)阳性对妊娠期糖尿病(GDM)发生风险和妊娠结局的影响。方法 288例妊娠早期孕妇为研究对象,其中, 185例TgAb阴性孕妇作为对照组, 103例TgAb阳性孕妇作为观察组。对比两组孕妇的检查指标及不良妊娠结局,分析GDM的影响因素。结果观察组孕妇的体质量指数(BMI)(27.35±0.54)kg/m^(2)、年龄(28.65±1.24)岁、腹围(83.56±5.21)cm、口服葡萄糖耐量试验(OGTT)后2 h血糖(5.98±0.78)mmol/L均高于对照组的(26.14±0.51)kg/m^(2)、(27.12±1.13)岁、(81.02±5.17)cm、(5.61±0.57)mmol/L,血肌酐(Cr)(46.21±4.85)μmol/L低于对照组的(50.47±4.73)μmol/L,差异具有统计学意义(P<0.05)。观察组孕妇的GDM、妊娠期高血压综合征(PIH)、自然流产、剖宫产、胎膜早破发生率分别为20.39%、26.21%、21.36%、9.71%、18.45%,均高于对照组的5.41%、7.03%、5.41%、1.62%、0.54%,差异具有统计学意义(P<0.05)。两组孕妇的贫血、早产、胎儿生长受限、低体重儿、胎盘早剥、巨大儿、羊水过少/过多、新生儿窒息发生率对比,差异无统计学意义(P>0.05)。Logistic回归分析显示, OGTT后2 h血糖、TgAb是GDM的独立危险因素(P<0.05)。结论 TgAb阳性可以增加GDM的发生风险,导致不良妊娠结局,需要高度关注危险因素,进而有效预防GDM。
Objective To analyzed the influence of thyroglobulin antibody(TgAb)positive in early pregnancy on the risk of gestational diabetes mellitus(GDM)and pregnancy outcome.Methods There were 288 cases of pregnant women in early pregnancy as the research subjects,of 185 cases of TGAb negative pregnant women as the control group,and 103 cases of TGAb positive pregnant women as the observation group.The examination indexes and adverse pregnancy outcomes of the two groups were compared,and the influencing factors of GDM were analyzed.Results The body mass index(BMI)(27.35±0.54)kg/m^(2),age(28.65±1.24)years old,abdominal circumference(83.56±5.21)cm,2 h blood glucose after oral glucose tolerance test(OGTT)(5.98±0.78)mmol/L of the observation group were higher than(26.14±0.51)kg/m^(2),(27.12±1.13)years old,(81.02±5.17)cm,(5.61±0.57)mmol/L of the control group,and blood creatinine(Cr)(46.21±4.85)μmol/L was lower than(50.47±4.73)μmol/L of the control group.All the difference was statistically significant(P<0.05).The incidences of GDM,pregnancy-induced hypertension(PIH),spontaneous abortion,cesarean section,and premature rupture of membranes in the observation group were 20.39%,26.21%,21.36%,9.71%and 18.45%,which were higher than 5.41%,7.03%,5.41%,1.62%and 0.54%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of anemia,premature birth,fetal growth restriction,low birth weight,placental abruption,macrosomia,oligohydramnios/hyperhydramnios,neonatal asphyxia between the two groups(P>0.05).Logistic regression analysis showed that 2 h blood glucose after OGTT and TGAb were independent risk factors for GDM(P<0.05).Conclusion TGAb positive can increase the risk of GDM and lead to adverse pregnancy outcomes,so close attention should be payed to the risk factors to effectively prevent GDM.
作者
付艳艳
FU Yan-yan(Baiyun District Maternal and Child Health Hospital,Guangzhou 510000,China)
出处
《中国现代药物应用》
2021年第12期72-75,共4页
Chinese Journal of Modern Drug Application
