摘要
急性肾损伤(acute kidney injury,AKI)是一种高发病率、高死亡率的危重疾病.除了支持性治疗,如血液透析和肾脏移植之外,暂时无针对性的治疗方法.因此需要从AKI发病机制着手,探索一种新型的治疗策略.近期研究表明,氧化应激是急性肾损伤的重要病理机制之一.因此,有针对性地缓解肾脏氧化应激成为AKI治疗的关键.具有还原性的功能纳米材料的发展为治疗急性肾损伤提供了新的思路和可能的途径.本文综述了近年来具有活性氧清除能力的功能纳米材料在AKI治疗中的研究进展.
Acute kidney injury(AKI)is a critical disease associated with high morbidity and mortality.Apart from hemodialysis and kidney transplantation,there is no targeted therapy.Therefore,it is necessary to start from the pathogenesis of AKI and explore new treatment strategies.Recent studies have shown that oxidative stress is an important pathological mechanism of AKI.Therefore,alleviating renal oxidative stress has become a key issue in the treatment of AKI.The development of functional nanomaterials with reducibility provides new ideas for AKI treatment.Here we reviewed the recent studies in the application of functional nanomaterials with active oxygen scavenging ability in the treatment of AKI.
作者
侯林倩
张瑞
仲晓燕
程亮
HOU LinQian;ZHANG Rui;ZHONG XiaoYan;CHENG Liang(Collaborative Innovation Center of Suzhou Nano Science and Technology,Institute of Functional Nano&Soft Materials(FUNSOM),Soochow University,Suzhou 215123,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2021年第5期507-517,共11页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:U20A20254,52072253)资助。
