摘要
目的探讨网织红细胞百分率(RET%)、高荧光强度网织红细胞百分率(HFR%)、中荧光强度网织红细胞百分率(MFR%)、低荧光强度网织红细胞百分率(LFR%)、未成熟网织红细胞比率(IRF%)、网织红细胞血红蛋白含量(RET-He)这些网织红细胞新参数对各类贫血性疾病的诊断价值,为贫血性疾病的诊断治疗提供参考依据。方法选取2017年8月至2020年3月在该院初诊为贫血的患者98例作为研究对象。根据贫血类型分为巨幼细胞性贫血组11例,溶血性贫血组16例,再生障碍性贫血组20例,缺铁性贫血组30例和肾病性贫血组21例。另选取该院体检健康者30例作为对照组。检测并分析各组网织红细胞新参数(RET%、HFR%、MFR%、LFR%、IRF%、RET-He)。结果与对照组比较,贫血组患者网织红细胞新参数RET%、HFR%、MFR%有不同程度的增高,缺铁性贫血组RET-He低于对照组,肾病性贫血组RET-He低于对照组,溶血性贫血组RET-He高于对照组,差异均有统计学意义(P<0.01)。经受试者工作特征(ROC)曲线分析,RET-He、RET%、LFR%、HFR%均对缺铁性贫血有较高定的诊断价值,其中RET-He诊断缺铁性贫血时的曲线下面积为0.978,敏感度和特异度分别为96.7%和96.7%。结论网织红细胞新参数RET-He、RET%、IRF%、LFR%、MFR%、HFR%对贫血性疾病的鉴别和诊断具有一定的应用价值,且简便、快速、价廉,值得临床推广应用。
Objective To study the diagnostic value of reticulocytes percentage(RET%),high fluorescence reticulocytes percentage(HFR%),medium fluorescence reticulocytes percentage(MFR%),low fluorescence reticulocytes percentage(LFR%),immature reticulocytes ratio(IRF%),reticulocytes hemoglobin content(RET-He)for various anemia diseases,so as to provide reference for diagnosis and treatment of anaemic diseases.Methods A total of 98 patients with anemia newly diagnosed in our hospital from August 2017 to March 2020 were selected as the research subjects.According to the type of anemia,they were divided into megaloblastic anemia group(11 cases),hemolytic anemia group(16 cases),aplastic anemia group(20 cases),iron deficiency anemia group(30 cases)and nephrotic anemia group(21 cases).Another 30 healthy subjects were selected as the control group.The related parameters of reticulocytes(RET%,HFR%,MFR%,LFR%,IRF%,RET-He)were detected and analyzed.Results Compared with the control group,reticulocyte parameters(RET%,HFR%and MFR%)were increased to varying degrees in the anemia group.RET-He in the iron-deficiency anemia group was lower than that in the control group,that in the nephrotic anemia group was lower than that in the control group,and that in the hemolytic anemia group was higher than that in the control group,with statistical significance(P<0.01).ROC curve analysis showed that RET-He,RET%,LFR%and HFR%all had high diagnostic value for iron deficiency anemia.The area under the curve of RET-He in the diagnosis of iron deficiency anemia was 0.978,and the sensitivity and specificity were 96.7%and 96.7%,respectively.Conclusion The reticulocyte parameters RET-He,RET%,IRF%,LFR%,MFR%and HFR%have certain application value in the differentiation and diagnosis of anaemic diseases,which are simple,rapid and inexpensive,and worthy of clinical application.
作者
贾连玲
欧红玲
王欢
赵海娇
李梦
王欣茹
JIA Lianling;OU Hongling;WANG Huan;ZHAO Haijiao;LI Meng;WANG Xinru(Department of Clinical Laboratory,PLA Rocket Force Characteristic Medical Center,Beijing,100088,China)
出处
《国际检验医学杂志》
CAS
2021年第13期1563-1566,共4页
International Journal of Laboratory Medicine
基金
全军医学科技青年培育计划孵育项目(16QNP30)。
