摘要
目的观察无创呼吸机联合N-乙酰半胱氨酸治疗急性呼吸衰竭的临床疗效。方法选取2017年4月至2020年3月该院收治的呼吸道炎症相关急性呼吸衰竭患者85例。按照随机数字表法分为对照组(43例)和观察组(42例)。两组患者均给予抗感染、止咳化痰及营养支持等对症治疗,对照组给予无创呼吸机辅助通气,观察组在对照组的基础上给予雾化吸入N-乙酰半胱氨酸治疗。两组患者均治疗5 d。比较两组患者临床疗效,治疗前后血氧饱和度(SaO2)、动脉血氧分压(PaO2)及动脉二氧化碳分压(PaCO2)等血气指标、肌酸激酶同工酶(CK-MB)水平,以及无创呼吸机治疗时间、住院时间、不良反应发生率。结果观察组患者治疗总有效率[95.24%(40/42)]高于对照组[79.07%(34/43)],差异有统计学意义(P<0.05);观察组患者治疗后的血气指标水平显著优于对照组,CK-MB水平低于对照组,差异均有统计学意义(P<0.05);观察组无创呼吸机治疗时间及住院时间均短于对照组,差异均有统计学意义(P<0.05);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论无创呼吸机联合N-乙酰半胱氨酸用于治疗急性呼吸衰竭具有良好的临床疗效,可有效改善患者血气指标,降低心肌损伤,缩短患者应用无创呼吸机时间及住院时间,且安全性高。
Objective To observe the clinical efficacy of non-invasive ventilator combined with N-acetylcysteine in the treatment of acute respiratory failure.Methods From April 2017 to March 2020,85 patients with acute respiratory failure caused by respiratory inflammation were selected and divided into control group(43 cases)and observation group(42 cases).Both groups were treated with anti-infection,cough,phlegm and nutritional support.The control group was given non-invasive ventilator assisted ventilation,while the observation group was given atomization N-acetylcysteine on the basis of control group.Both groups were treated for 5 days.The curative effect of the two groups was observed,blood gas indexes such as SaO2,PaO2 and PaCO2,and CK-MB levels before and after treatment were measured,the treatment time,hospitalization time and incidence of adverse reactions were compared between the two groups.Results The total effective rate of observation group[95.24%(40/42)]was higher than that of control group[79.07%(34/43)],and the difference was statistically significant(P<0.05).After treatment,the blood gas index levels in the observation group were significantly better than those in the control group,while the CK-MB level was lower than that in the control group,with statistical significance(P<0.05).The time of non-invasive ventilator treatment and hospital stay in the observation group were shorter than those in the control group,with statistical significance(P<0.05).There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Noninvasive ventilator combined with N-acetylcysteine in the treatment of acute respiratory failure has good clinical efficacy,which can effectively improve the blood gas index of patients,reduce myocardial injury,shorten the time of non-invasive ventilator application and hospital stay,and has high safety.
作者
李英明
郑冉冉
谢丰建
LI Yingming;ZHENG Ranran;XIE Fengjian(Department of Emergency Medicine,Chizhou People′s Hospital,Chizhou,Anhui 247000,China)
出处
《国际检验医学杂志》
CAS
2021年第13期1639-1641,共3页
International Journal of Laboratory Medicine
