摘要
目的旨在探讨全麻药物对患者术后认知功能障碍的作用机制及构建其在影响记忆方面的调控网络。方法利用GO和KEGG数据库对麻醉相关基因进行功能注释及通路分析,并初步建立麻醉基因参与的调控网络。结果 GO分析结果显示,C-fos、HIF-1α、STAT3、Bcl-2在分子功能和生物过程方面均发挥重要作用,同时结合KEGG数据库成功绘制出以这四个基因为中心的相关基因的调控网络图。结论本研究通过对全麻药物对患者术后认知功能障碍的作用机制的生物学功能分析,并建立相关调控网络,为探讨全身麻醉药物所引起的术后认知功能障碍的作用机制提供理论依据。
Objective To explore the mechanism of general anesthetics on postoperative cognitive dysfunction and construct its regulatory network in the mechanism of memory.Methods Functional annotation and pathway analysis of related genes were performed using Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) databases.Results The results of GO analysis showed that C-fos, HIF-1α,STAT3 and Bcl-2 played important roles in molecular functions and biological processes.At the same time, combined with the KEGG database, a regulatory network map of related genes centering on the four genes were successfully drawn.Conclusion This study provides a theoretical basis for exploring the mechanism of postoperative cognitive dysfunction caused by general anesthetics by analyzing the biological function of the mechanism of general anesthetic drugs on postoperative cognitive dysfunction and establishing a related regulatory network.
作者
沈园园
蒋铭
王军
颜朋朋
陈甜甜
李杏瑞
Shen Yuanyuan;Jiang Ming;Wang Jun;Yan Pengpeng;Chen Tiantian;Li Xingrui(Luoyang No.1 Hospital of TCM,Luoyang,471000)
出处
《辽宁医学杂志》
2021年第3期80-85,共6页
Medical Journal of Liaoning
