摘要
近年来,随着纳米生物医学的进步和光学成像技术的兴起,分子影像学呈现出与材料学、化学、医用物理学、生物医学工程和基因组学等多个学科紧密融合的发展态势,基于纳米技术的新型分子显像剂迅速发展,以小分子、肽、抗体和适体修饰的纳米粒子已广泛应用于临床前研究和临床转化,分子影像技术在临床诊疗中有重大突破并取得一系列研究成果。多模态分子成像技术在精准诊疗中崭露头角,新一轮成像技术的升级能获取更多组织和分子层面的信息,进一步促进学科之间的交叉融合。本文着重从光学和光声分子影像、磁共振分子影像和正电子发射断层扫描分子影像3个方面的前沿技术和临床应用做一综述。
With the progress of nanobiotechnology and the rise of optical imaging technology recently,molecular imaging has shown a development trend of close integration with many disciplines such as materials science,chemistry,medical physics,biomedical engineering and genomics,etc.New molecular imaging agents based on nanotechnology are developing rapidly,and nanoparticles modified with small molecules,peptides,antibodies and aptamers have been widely used in preclinical research and clinical translation.Multimodal molecular imaging technology has emerged as a key component of precision medicine,and a new wave of imaging technology upgrades can obtain more information at the tissue and molecular levels,further promoting cross-fertilization between disciplines.In this paper,we review the cutting-edge technologies and clinical applications of optical and photoacoustic molecular imaging,magnetic resonance molecular imaging,and positron emission tomography molecular imaging.
作者
林盼盼
贾岩龙
黄淮栋
黄恺
吴仁华
LIN Panpan;JIA Yanlong;HUANG Huaidong;HUANG Kai;WU Renhua(Department of Radiology,the Affiliated Second Hospital of Shantou University Medical School,Shantou 515000,China;School of Clinical Medicine,Quanzhou Medical College,Quanzhou 362000,China;Department of Radiology,Xiangyang Central Hospital,Affiliated Hospital of Hubei College of Arts and Sciences,Xiangyang 441100,China;Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer,Shantou 515000,China)
出处
《分子影像学杂志》
2021年第4期710-713,共4页
Journal of Molecular Imaging
基金
国际(地区)合作与交流项目(82020108016)
国家自然科学基金(31870981)
广东省高水平大学建设计划临床医学重点建设学科专项资金(002-18120302)。
关键词
分子影像学
光声层析成像
纳米生物学技术
化学交换饱和转移
类淋巴系统
molecular imaging
photoacoustic tomography
nanobiotechnology
chemical exchange saturation transfer
glymphatic systems
