摘要
目的评估厦门市实施入境人员“14+7隔离”与“核酸+总抗体筛查”策略(联合筛查策略)对发现境外输入性新型冠状病毒(新冠病毒)感染者的作用。方法研究对象为2020年3月17日至12月31日厦门市入境人员、7月18日至12月31日外地隔离不足21 d的入境人员。收集和分析实施联合筛查策略后的境外输入性新型冠状病毒感染者的发现时间、路径和检测情况。结果在174628名入境人员和943名外地入境人员中,共发现304例境外输入性新冠病毒感染者,其中163例(53.6%)为总抗体阳性后经多次及多部位核酸检测确诊,27例(8.9%)在入境14 d后首次核酸阳性,136例入境“14 d”隔离期间首次核酸检测阳性,仅8例在总抗体阳性后首次核酸检测阳性,128例在平均2.3次(最高6次)核酸检测阴性后转为阳性。联合筛查策略比“14 d隔离+核酸筛查”策略估算多检出155例,占入境感染者总数的51.0%,提高检出率约1倍。截至2021年2月26日尚未发现厦门市入境人员引起的续发感染。结论厦门市对入境人员实施联合筛查策略,可有效筛查入境14 d后转为核酸阳性的新冠病毒感染者,与“14 d隔离+核酸筛查”策略相比,有效提高检出率,降低境外输入引起续发传播的风险。
Objective To analysis effectiveness of the"14 plus 7 day quarantine"and"nucleic acid plus total antibody testing"strategy(combined screening strategy)for screenin the imported patients with COVID-19 in Xiamen.Methods The study populations were overseas travelers arriving in Xiamen from March 17 to December 31,2020,and overseas travelers who had quarantine outside Xiamen for less than 21 days from July 18 to December 31,2020.Data were collected and analyzed on the timing of detection,pathways,and test results of the imported patients with COVID-19 after implementing combined screening strategy.Results A total of 304 imported patients with COVID-19 were found from 174628 overseas travelers and 943 overseas travelers from other cities.A total of 163 cases(53.6%)were diagnosed by multitime,multisite intensive nucleic acid testing after positive finding in total antibody testing.Among them,27(8.9%)were first positive for nucleic acid in 14 plus 7 day quarantine and 136 were first positive for nucleic acid in 14-day quarantine.Only 8 of these individuals were tested positive for nucleic acid after positive total antibody testing.The other 128 individuals were tested positive for nucleic acid after being negative for average 2.3 times(maximum of 6 times).Aditional 155 cases might be detected by using the combined"14 plus 7 day quarantine"and"nucleic acid plus total antibody testing"strategy compared with"14-day quarantine and nucleic acid testing"strategy,accounting for 51.0%of the total inbound infections.So the combined screening strategy doubled the detection rate for imported patients with COVID-19.No second-generation case caused by overseas travelers had been reported in Xiamen as of February 26,2021.Conclusions Xiamen's combined screening strategy can effectively screen the imported patients with COVID-19 who were first positive for nucleic acid after 14 day quarantine.Compared with"14 day quarantine and nucleic acid testing",the combined screening strategy improved detection rate and further reduced the risk of the secondary transmission caused by the imported patients with COVID-19.
作者
沈理通
段振华
陈泽辉
杨天赐
林涛
张荣秋
蒋丽娜
曾小红
温慧欣
詹钦勇
苏迎盈
张雅丽
彭质斌
郑建东
郑蓉蓉
秦颖
袁权
陈长荣
Shen Litong;Duan Zhenhua;Chen Zehui;Yang Tianci;Lin Tao;Zhang Rongqiu;Jiang Lina;Zeng Xiaohong;Wen Huixin;Zhan Qinyong;Su Yingying;Zhang Yali;Peng Zhibin;Zheng Jiandong;Zheng Rongrong;Qin Ying;Yuan Quan;Chen Changrong(Department of Public Health Mornitoring,Xiamen Center for Disease Control and Prevention,Xiamen 361021,China;Chengdu Workstation for Emerging Infectious Disease Control and Prevention,Chengdu Center for Disease Control and Prevention,Chengdu 610041,China;Laboratory,Xiamen Center for Disease Control and Prevention,Xiamen 361021,China;Clinical Laboratory Center,Zhongshan Hospital Affiliated to Xiamen University,Xiamen 361004,China;Xiamen Municipal Health Commission,Xiamen 361003,China;Xiamen Center for Disease Control and Prevention,Xiamen 361021,China;National Institute of Diagnostics and Vaccine Development in Infectious Disease,Xiamen University,Xiamen 361102,China;Division of Infectious Disease,Key Laboratory of Infectious Disease Surveillance and Early-warning,Chinese Center for Disease Control and Prevention,Beijing 102206,China)
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2021年第6期1002-1007,共6页
Chinese Journal of Epidemiology
